Table 2

Top 10 genetic loci associated with smoking initiation (ever vs never smoker), stratified by sex

Nearest geneLocusSNP markerMAMAFp Value
Ever smokersNever smokers
Men
 SLC39A1117q21.31rs2567519A0.390.461.33×10−7
 SLC39A1117q21.31rs2714017T0.390.471.34×10−7
 MIR1305||TENM34q35.1rs11724903G0.090.132.90×10−7
 SLC39A1117q21.31rs7406107G0.430.514.32×10−7
 SLC39A1117q21.31rs2714016A0.390.475.06×10−7
 SLC39A1117q21.31rs2714018A0.390.477.49×10−7
 SLC39A1117q21.31rs4793310C0.410.487.67×10−7
 LINC006072q35rs4674024A0.340.411.52×10−6
 MAT2B||LOC1004197165q33rs292404G0.130.181.72×10−6
 MAT2B||LOC1004197165q33rs10057965C0.210.262.74×10−6
Women
 PAGE3||MAGEH1Xp11.21rs4240023A0.070.027.79×10−8
 SLCO3A1||ST8SIA215q26rs12912184A0.260.349.32×10−8
 MIR4536–1Xp11.21rs4826404G0.070.029.37×10−8
 RRAGB||LOC644924Xp11.21rs4826434C0.070.021.06×10−7
 USP51Xp11.21rs2499862A0.070.021.20×10−7
 XAGE-4Xp11.21rs4265330C0.070.022.02×10−7
 SLCO3A1||ST8SIA215q26rs12901615A0.260.342.21×10−7
 XAGE-4||RRAGBXp11.21rs5914419A0.070.022.78×10−7
 RRAGB||LOC644924Xp11.21rs2375467A0.070.022.81×10−7
 RRAGB||LOC644924Xp11.21rs1325570A0.070.022.84×10−7

  • MA, Minor allele; MAF, minor allele frequency; SNP, single nucleotide polymorphism.