Table 1

AMOVA for 32 absorption, distribution, metabolism and excretion core genes based on all SNPs in each gene region in three groups: Europeans (CEU and TSI), East Asians (CHB and JPT) and five ethnic groups in northwestern China (TJK, UIG, KZK, KGZ and HUI)

Type	Gene	Variant (%)			F_ST	p Value
Type	Gene	Between group	Within group	Within populations	F_ST	p Value
Phase I	CYP1A1	20.43	4.70	74.87	0.251	0.0000
	CYP1A2	9.52	1.99	88.49	0.115	0.0000
	CYP2A6	−1.41	2.43	98.98	0.010	0.0020
	CYP2B6	1.18	−0.28	99.10	0.009	0.0176
	CYP2C8	3.70	1.29	95.01	0.050	0.0000
	CYP2C9	2.82	1.05	96.13	0.039	0.0000
	CYP2C19	1.31	1.12	97.57	0.024	0.0000
	CYP2D6	4.49	1.34	94.17	0.058	0.0000
	CYP2E1	5.99	0.47	93.53	0.065	0.0000
	CYP3A4	11.10	−0.46	89.36	0.106	0.0000
	CYP3A5	11.24	−0.53	89.29	0.107	0.0000
	DPYD	1.50	1.90	96.60	0.034	0.0000
Phase II	GSTM1	−0.53	1.10	99.43	0.006	0.0616
	GSTP1	5.59	1.39	93.03	0.070	0.0000
	GSTT1	3.32	4.21	92.47	0.075	0.0000
	NAT1	5.42	0.38	94.20	0.058	0.0000
	NAT2	7.37	2.90	89.73	0.103	0.0000
	SULT1A1	4.55	0.90	94.56	0.054	0.0000
	TPMT	1.35	−0.41	99.06	0.009	0.0166
	UGT1A1	1.04	3.48	95.48	0.045	0.0000
	UGT2B7	3.27	1.04	95.69	0.043	0.0000
	UGT2B15	−1.01	2.88	98.13	0.019	0.0000
	UGT2B17	3.58	−0.73	97.15	0.029	0.0010
Transporter	ABCB1	6.30	1.35	92.36	0.076	0.0000
	ABCC2	0.85	1.81	97.34	0.027	0.0000
	ABCG2	2.90	1.70	95.40	0.046	0.0000
	SLC15A2	1.21	5.24	93.54	0.065	0.0000
	SLC22A1	3.11	1.90	95.00	0.050	0.0000
	SLC22A2	1.98	0.36	97.66	0.023	0.0000
	SLC22A6	4.31	0.96	94.73	0.053	0.0000
	SLCO1B1	6.81	3.02	90.17	0.098	0.0000
	SLCO1B3	2.48	1.50	96.02	0.040	0.0000

HUI, Hui; KGZ, Kirgiz; KZK, Kazakh; TJK, Tajik; UIG, Uyghur.