Table 2

Genetic studies of FAM13A

CohortFAM13A SNPsPatients, nTrait/phenotypeReferences
Population basedrs2869967, rs683097020890*FEV1/FVC6
rs76711671996FEV1, FVC7
rs2609264, rs2609260, rs2609261, rs1458551, rs2609255, rs2464528, rs2609265, rs2609262, rs12466426223FEV1/FVC26
COPDrs1903003, rs7671167, rs28699672940Cases vs controls10
rs76711671609Emphysema13
rs7671167224†FEV1/FVC
rs10075901609FEV1
rs2869966, rs2869967, rs20455171609FEV1/FVC
rs2869967275Cases vs controls12
rs7671167458Cases vs controls19
rs1964516, rs76711673499*Cases vs controls14
rs7671167
rs7671167
315
645‡
FEV1/FVC
FEV1/FVC
15
rs7671167
rs6830970
204
680
Cases vs Controls (former smokers)
FEV1/FVC
18
rs7671167, rs2869966, rs2869967, rs2045517, rs68309701367‡FEV1/FVC
rs76711673424Cases vs Controls17
rs7671167236FEV1, FEV1/FVC9
rs2609264, rs2609260, rs26092611000Cases vs controls, FEV1/FVC16
rs2609264, rs2609260, rs26092612000‡FEV1, FEV1/FVC
rs44164426633*Cases vs controls11
Lung cancerrs7671167446Cases vs controls19
IIPrs2609255876*Cases vs controls22
Asthmars2869967, rs68309701441*FVC21
rs2869967, rs68259981544*FEV1/FVC20
  • *Meta-analysis.

  • †Families.

  • ‡All subjects: COPD+controls.

  • COPD, chronic obstructive pulmonary disease; IIP, idiopathic interstitial pneumonia; FEV1, forced expiratory volume in 1s; FVC, forced vital capacity. SNPs in italic are imputated SNPs.