Effect of hearing test on association
| All studies | |||
|---|---|---|---|
| Variant | OR | 95% CI | N |
| MT-RNR1m.961T>C | −0.61 | (−1.23 to 0.023) | 5654 |
| MT-RNR1m.988G>A | 1.94 | (0.59 to 3.29) | 1430 |
| MT-RNR1m.1009C>T | −0.62 | (−1.2 to −0.04) | 5311 |
| MT-RNR1m.1095T>C | 0.73 | (−0.025 to 1.50) | 6882 |
| MT-RNR1m.1382A>C | 0.4 | (0.01 to 0.8) | 4867 |
| MT-RNR1m.1494C>T | 1.19 | (0.18 to 2.19) | 10 353 |
| MT-RNR1m.1557A>C | −4.43 | (−7.25 to −1.61) | 264 |
| MT-RNR1m.1555A>G | 1.9 | (1.34 to 2.46) | 29 967 |
| Variant | OR | OR p value | N |
| 3.1 Pure tone audiometry | |||
| MT-RNR1m.961T>C | −0.55 | 0.109 | 5164 |
| MT-RNR1m.988G>A | 1.94 | 0.005 | 1430 |
| MT-RNR1m.1009C>T | −0.62 | 0.037 | 5311 |
| MT-RNR1m.1095T>C | 1.21 | 0.025 | 5205 |
| MT-RNR1m.1382A>C | 0.4 | 0.046 | 4867 |
| MT-RNR1m.1494C>T | 1.19 | 0.046 | 9291 |
| MT-RNR1m.1557A>C | −4.43 | 0.002 | 264 |
| MT-RNR1m.1555A>G | 2.28 | <0.001 | 10 212 |
| 3.2 CT | |||
| MT-RNR1m.1095T>C | 0.46 | 0.489 | 937 |
| MT-RNR1m.1494C>T | −0.07 | 0.971 | 220 |
| MT-RNR1m.1555A>G - | 1.69 | 0.14 | 1139 |
| 3.3 Auditory brainstem response | |||
| MT-RNR1m.961T>C | −0.55 | 0.109 | 5164 |
| MT-RNR1m.988G>A | 2.21 | 0.138 | 500 |
| MT-RNR1m.1009C>T | −0.62 | 0.037 | 5311 |
| MT-RNR1m.1095T>C | 1.37 | 0.019 | 4275 |
| MT-RNR1m.1382A>C | 0.4 | 0.046 | 4867 |
| MT-RNR1m.1494C>T | 1.35 | 0.026 | 5919 |
| MT-RNR1m.1555A>G | 2.2 | <0.001 | 22 743 |
| 3.4 Otoacoustic emission | |||
| MT-RNR1m.961T>C | −0.55 | 0.109 | 5164 |
| MT-RNR1m.988G>A | 1.87 | 0.016 | 930 |
| MT-RNR1m.1009C>T | −0.68 | 0.025 | 4867 |
| MT-RNR1m.1095T>C | 1.21 | 0.025 | 5205 |
| MT-RNR1m.1382A>C | 0.4 | 0.046 | 4867 |
| MT-RNR1m.1494C>T | 1.75 | 0.011 | 5123 |
| MT-RNR1m.1555A>G | 2.06 | <0.001 | 23 538 |