Diagnostic Test (2 × 2 tables) analysis for the identification of MLH1 mutation carriers
| Sensitivity (95% CI) | Specificity (95% CI) | |
|---|---|---|
| Normal MLH1 promoter region | 94.37% (86.20% to 98.44%) | 87.67% (77.88% to 94.2%) |
| wt BRAF p.V600E | 98.59% (92.4% to 99.96%) | 65.75% (53.72% to 76.47%) |
| wt BRAF c.1799T>A p.Val600Glu OR normal MLH1 promoter region | 100% (94.94% to 100%) | 63.01% (50.91% to 74.03%) |
| wt BRAF c.1799T>A p.Val600Glu AND normal MLH1 promoter region | 92.96% (84.33% to 97.67%) | 90.41% (81.24% to 96.06%) |