Table 2

Above-threshold SCQ scores in male and female RASopathy subjects and healthy siblings

Males/femalesMales with SCQ≥15 (%)Females with SCQ≥15 (%)ORp Value
All RASopathies102/10939 (38)18 (17)3.10.0003
NF126/407 (27)0 (0)0.0008
CS22/218 (36)3 (14)3.40.095
NS26/226 (23)4 (18)1.40.48
CFC28/2618 (64)11 (42)2.50.0891
Siblings66/510 (0)0 (0)1.0
  • The percentage of males and females within each group who scored 15 or higher on the SCQ are shown. OR=Odds Ratio showing male compared with female prevalence. One-tailed Fisher's Exact test p values are calculated as shown.

  • CFC, cardio-facio-cutaneous syndrome; CS, Costello syndrome; NF1, neurofibromatosis type 1; NS, Noonan syndrome; SCQ, Social Communication Questionnaire.