The candidate loci where only the affected brothers in the respective families are homozygous for a haplotype possibly IBD from a recent ancestor
| Shared patient haplotype | Shared parental haplotype | ||||||
|---|---|---|---|---|---|---|---|
| Locus | LOD score* | Begins (bp) | Ends (bp) | Size (Mb) | Begins (bp) | Ends (bp) | Size (Mb) |
| Family 1 | |||||||
| 4p16.2 | 3.01 (3.01) | rs4689888 (4 569 460) | rs17779675 (6 449 514) | 1.88 | rs4689888 (4 569 460) | rs1400931 (18 752 731) | 14.18 |
| 7q22.1 | 2.8 (3.01) | rs4236541 (98 830 439) | rs28365067 (99 272 310) | 0.44 | rs4729320 (96 551 820) | rs6967487 (99 602 191) | 3.05 |
| 5p15.31 | 0 (3.01) | rs186893 (8 473 747) | rs17225452 (8 873 310) | 0.39 | Same as in patients (three different haplotypes) | 0.39 | |
| 18q11.1 | 2.98 (3.01) | rs2339102 (23 797 853) | rs1609839 (24 027 419) | 0.23 | rs12959318 (11 643 985) | rs12456229 (75 118 412) | 63.47 |
| Family 2 | |||||||
| 17pter-p22.1 | 2.53 (2.53) | pter (0) | rs3744405 (7 193 255) | 7.19 | Same as in patients | 7.19 | |
| 14q11.2–12 | 2.53 (2.53) | rs8010057 (23 506 110) | rs2332572 (26 341 293) | 2.83 | rs8010057 (23 506 110) | rs1952267 (29 889 699) | 6.38 |
| 7q36.2 | 2.48 (2.51) | rs4621714 (153 356 432) | rs10229774 (153 652 188) | 0.29 | Same as in patients | 0.29 | |
*LOD scores obtained after detailed calculations are given in parentheses.
IBD, identical by descent; LOD, logarithm of the odds.