Table 2

SNPs associated with testosterone, oestradiol, FSH and SHBG at genome-wide level

SNPChr (BP)GeneLocationA1/A2First stage (N=1999)Second stage (N=1496)Combined (N=3495)Variance (%)*
MAFβ (SE)p ValueMAFβ (SE)p ValueMAFβ (SE)p Value
Testosterone
 rs207523017 (7 427 832)SHBG5′ upstreamG/A0.30−0.25 (0.06)1.56×10−50.28−0.30 (0.08)1.82×10−40.29−0.28 (0.05)1.13×10−80.7
SHBG†
 rs207523017 (7 427 832)SHBG5′ upstreamG/A0.30−0.09 (0.01)7.66×10−120.28−0.09 (0.02)2.31×10−70.29−0.09 (0.01)4.75×10−191.2
Oestradiol†
 rs241409515 (49 311 584)CYP19A1IntronA/G0.32−0.09 (0.01)4.59×10−170.31−0.08 (0.01)1.47×10−150.31−0.08 (0.01)6.54×10−313.9
 rs244576215 (49 405 000)CYP19A1IntronC/T0.29−0.06 (0.01)2.38×10−210.27−0.06 (0.01)5.39×10−80.28−0.08 (0.01)7.75×10−283.2
FSH†
 rs241409515 (49 311 584)CYP19A1IntronA/G0.320.12 (0.02)7.66×10−130.310.08 (0.02)3.10×10−50.310.11 (0.01)1.59×10−161.5
  • *Variance: Percentage of phenotypic variance explained by the SNP.

  • †β are log-transformed were for these variables.

  • A1, minor allele; A2, major allele; FAS, follicle-stimulating hormone; MAF, minor allele frequency; SHBG, sex hormone binding globulin; SNP, single nucleotide polymorphism.