Table 3

Occurrence of clinically atypical nevi in families with CDK4 germline mutations

CDK4 positive family members
CDK4 negative family membersAffectedUnaffected
Clinically atypical nevi*N=49 (%)N=50 (%)p Value†N=20 (%)p Value†
Present13 (26.5)35 (70.0)<0.00115 (75.0)<0.001
Not present36 (73.5)15 (30.0)5 (25.0)
  • *Data on CDK4 mutation status and clinically atypical nevi were available for 119 subjects.

  • CDK4 negative family members were compared with affected and with unaffected CDK4 positive family members, respectively.