Table 3

Results for SNPs associated with testosterone and SHBG (p<5×10−8 in previous GWAS) in our first-stage GWAS (N=1999)

SNPCytobandBPGeneA1/A2First stage (N=1999)Reference
MAF*β (SE)p Value
Testosterone
 rs1082218610q2165 020 389JMJD1CG/A0.390.02 (0.01)0.1018
 rs72742817p137 478 517SHBGA/G0.41−0.07 (0.05)0.2118
 rs5934505Xp228 873 826FAM9BG/A0.250.09 (0.09)0.2820
SHBG†
 rs174963321p13107 347 898PRMT6G/A0.310.01 (0.01)0.2922
 rs7800932p2327 596 107GCKRA/G0.38−0.04 (0.01)1.48×10−422
 rs37791957q2197 831 298BAIAP2L1A/T0.27−0.03 (0.01)0.0522
 rs4408378q2181 624 529ZBTB10G/A0.210.01 (0.01)0.6222
 rs791092710q2164 808 916JMJD1C1G/T0.290.02 (0.01)0.0922
 rs414905612p1221 222 816SLCO1B1G/A0.13−0.03 (0.02)0.1422
 rs802358015q2694 509 295NR2F2G/A0.450.05 (0.01)1.47×10−522
 rs72742817p137 478 517SHBGA/G0.41−0.05 (0.01)2.57×10−519
 rs241198417q2144 800 750ZNF652A/G0.300.02 (0.01)0.1722
 rs1573036†Xq22109 706 724TDGF3G/A0.010.09 (0.05)0.0822
  • *β was log-transformed.

  • †rs1573036 is presented by rs7050023, which is in complete LD with it (r2=1).

  • A1, minor allele; A2, major allele; GWAS, genome-wide association studies; MAF, minor allele frequency; SHBG, sex hormone binding globulin; SNP, single nucleotide polymorphism.