Estimated ovarian cancer familial relative risks (FRRs) by the distribution of the polygenic risk score (PRS) in the proband
| Proband PRS quartile | Observed | Expected | FRR | Robust 95% CI |
|---|---|---|---|---|
| All | ||||
| 0–25% | 13 | 6.14 | 2.12 | 1.18 to 3.80 |
| 25–50% | 17 | 6.44 | 2.64 | 1.60 to 4.36 |
| 50–75% | 25 | 6.52 | 3.83 | 2.56 to 5.73 |
| 75–100% | 16 | 6.13 | 2.61 | 1.61 to 4.24 |
| Proband has serous tumour | ||||
| 0–25% | 7 | 2.55 | 2.74 | 1.17 to 6.41 |
| 25–50% | 11 | 3.21 | 3.43 | 1.92 to 6.14 |
| 50–75% | 17 | 3.45 | 4.92 | 3.00 to 8.06 |
| 75–100% | 8 | 3.34 | 2.39 | 1.21 to 4.71 |
| Non-BRCA1 or BRCA2 probands | ||||
| 0–25% | 12 | 5.85 | 2.05 | 1.11 to 3.79 |
| 25–50% | 12 | 6.16 | 1.95 | 1.11 to 3.41 |
| 50–75% | 15 | 6.09 | 2.46 | 1.45 to 4.18 |
| 75–100% | 11 | 5.61 | 1.96 | 1.09 to 3.53 |