Association statistics for papillary thyroid cancer (PTC) and benign thyroid tumour (BN) risk and genetic variants
| Genotypes, risk allele | PTC | BN | Control | PTC vs control* | BN vs control* | ||
|---|---|---|---|---|---|---|---|
| OR (95% CI)† | p Value† | OR (95% CI)† | p Value† | ||||
| rs944289, located at 14q13.3 | |||||||
| CC | 179 (21.2%) | 140 (27.8%) | 349 (34.7%) | 1 (Reference)c | 1.593e-10c | 1 (Reference)c | 0.0076c |
| CT | 443 (52.4%) | 238 (47.3%) | 461 (45.9%) | 1.86 (1.49 to 2.33)c | 1.28 (1.00 to 1.65)c | ||
| TT | 223 (26.4%) | 125 (24.9%) | 195 (19.4%) | 2.28 (1.75 to 2.97)c | 1.60 (1.19 to 2.16)c | ||
| CT+TT | 666 (78.8%) | 363 (72.2%) | 656 (65.3%) | 1.99 (1.61 to 2.45) d | 8.007e-11d | 1.38 (1.09 to 1.74)d | 0.0070d |
| Allele T | 52.6% | 48.5% | 42.3% | 1.53 (1.34 to 1.74) | 2.028e-10 | 1.28 (1.10 to 1.50) | 0.0014 |
| rs965513, located at 9q22.33 | |||||||
| GG | 654 (77.4%) | 421 (83.7%) | 850 (84.6%) | 1 (Reference)c | 5.181e-4c | 1 (Reference)c | 0.7460c |
| GA | 181 (21.4%) | 77 (15.3%) | 147 (14.6%) | 1.59 (1.25 to 2.02)c | 1.08 (0.80 to 1.46)c | ||
| AA | 10 (1.20%) | 5 (1%) | 8 (0.80%) | 1.69 (0.66 to 4.33)c | 1.43 (0.46 to 4.42)c | ||
| GA+AA | 191 (22.6%) | 82 (16.3%) | 155 (15.4%) | 1.59 (1.26 to 2.02)d | 1.013e-4d | 1.10 (0.82 to 1.47)d | 0.5438d |
| Allele A | 11.9% | 8.6% | 8.1% | 1.53 (1.23 to 1.90) | 1.436e-4 | 1.10 (0.84 to 1.45) | 0.4795 |
| rs966423, located at 2q35 | |||||||
| CC | 566 (67.0%) | 311 (61.8%) | 602 (59.9%) | 1 (Reference)c | 3.799e-3c | 1 (Reference)c | 0.5181c |
| CT | 256 (30.3%) | 176 (35%) | 360 (35.8%) | 0.76 (0.62 to 0.92)c | 0.94 (0.75 to 1.18)c | ||
| TT | 23 (2.7%) | 16 (3.2%) | 43 (4.3%) | 0.56 (0.33 to 0.94)c | 0.72 (0.40 to 1.31)c | ||
| CT+TT | 279 (33.0%) | 192 (38.2%) | 403 (40.1%) | 0.74 (0.61 to 0.89)d | 1.688e-3d | 0.92 (0.74 to 1.15)d | 0.4501d |
| Allele C | 82.1% | 79.3% | 77.8% | 1.31 (1.12 to 1.55) | 0.0010 | 1.10 (0.91 to 1.32) | 0.3339 |
| rs2439302, located at 8p12 | |||||||
| CC | 501 (59.3%) | 344 (68.4%) | 682 (67.9%) | 1 (Reference)c | 1.797e-4c | 1 (Reference)c | 0.9346c |
| GC | 295 (34.9%) | 144 (28.6%) | 289 (28.7%) | 1.39 (1.14 to 1.70)c | 0.99 (0.78 to 1.25)c | ||
| GG | 49 (5.8%) | 15 (3%) | 34 (3.4%) | 2.00 (1.27 to 3.14)c | 0.89 (0.48 to 1.66)c | ||
| GC+GG | 344 (40.7%) | 159 (31.6%) | 323 (32.1%) | 1.46 (1.20 to 1.76)d | 1.096e-4d | 0.98 (0.78 to 1.23)d | 0.8471d |
| Allele G | 23.3% | 17.3% | 17.8% | 1.41 (1.20 to 1.66) | 2.776e-5 | 0.97 (0.80 to 1.19) | 0.7779 |
| rs6983267, located at 8q24 | |||||||
| TT | 287 (34%) | 156 (31.0%) | 340 (33.8%) | 1 (Reference)c | 0.9622c | 1 (Reference)c | 0.5458c |
| TG | 403 (47.7%) | 249 (49.5%) | 484 (48.2%) | 0.98 (0.80 to 1.20)c | 1.18 (0.86 to 1.60)c | ||
| GG | 155 (18.3%) | 98 (19.5%) | 181 (18%) | 1.01 (0.78 to 1.32)c | 1.11 (0.87 to 1.42)c | ||
| TG+GG | 558 (66%) | 347 (69.0%) | 665 (66.2%) | 0.99 (0.82 to 1.20)d | 0.9168d | 1.13 (0.90 to 1.42)d | 0.2988d |
| GG | 155 (18.3%) | 98 (19.5%) | 181 (18%) | 1.03 (0.81 to 1.30)r | 0.8360r | 1.10 (0.84 to 1.45)r | 0.4884r |
| TG | 403 (47.7%) | 249 (49.5%) | 484 (48.2%) | 0.98 (0.81 to 1.17)o | 0.7959o | 1.05 (0.85 to 1.30)o | 0.6645o |
| Allele G | 42.2% | 44.2% | 42.1% | 1.00 (0.87 to 1.14) | 0.9654 | 1.11 (0.93 to 1.27) | 0.2797 |
*Adjusted by age and gender using unconditional logistic regression model.
†The model of inheritance: c, codominant; d, dominant; o, overdominant; r, recessive.