Table 1

Association results for rs3827440 using two methods

StageSexNo. of cases (%)No. of controls (%)p ValueOR (95% CI)*
TT/TCC/CTCTT/TCC/CTCLogistic regressionsnpMatrix
GWASFemale444 (39.8)163 (14.6)508 (45.6)367 (32.6)219 (19.4)541 (48.0)1.63 (1.27 to 2.08)
Male232 (68.0)109 (32.0)186 (52.0)172 (48.0)1.97 (1.45 to 2.68)
Combined676 (46.4)272 (18.7)508 (34.9)553 (37.2)391 (26.3)541 (36.4)9.52×10−84.60×10−91.76 (1.45 to 2.13)
ReplicationFemale1298 (38.5)471 (14.0)1606 (47.6)957 (33.2)584 (20.2)1344 (46.6)1.68 (1.45 to 1.95)
Male606 (68.1)284 (31.9)526 (57.0)396 (43.0)1.60 (1.33 to 1.95)
Combined1904 (44.6)755 (17.7)1606 (37.7)1483 (39.0)980 (25.7)1344 (35.3)7.76×10−151.71×10−151.67 (1.48 to 1.87)
Meta-analysis5.53×10−214.26×10−221.69 (1.53 to 1.86)
  • *In females, the ORs were estimated as the ORs of TT genotypes. In males, the ORs were estimated as the per allele ORs. In the mixed sex samples, the ORs were estimated as the ORs of the combined TT and T genotypes.

  • GWAS, genome-wide association studies.