Gene | SNP* | Location | Major allele | Minor allele | MAF | HR (95% CI)† | p Value† |
---|---|---|---|---|---|---|---|
EPHA4 | rs17348202 | 210 kb downstream | G | A | 0.05 | 4.85 (2.57 to 9.13) | 1.02×10−6 |
EPHA6 | rs301927 | In gene (intronic) | G | A | 0.17 | 2.35 (1.57 to 3.53) | 3.44×10−5 |
EPHA5 | rs1159057‡ | 48 kb downstream, LD covers gene | A | G | 0.44 | 2.01 (1.43 to 2.84) | 6.84×10−5 |
EPHA8 | rs209709 | 12 kb upstream | G | A | 0.17 | 2.20 (1.36 to 3.55) | 1.28×10−3 |
*Genotyped SNPs in EPHA genes associated with neuropathy at p<0.005. SNPs shown in the table are those with the lowest p value for each gene.
†Estimated by multivariable Cox regression analysis adjusted for age.
‡rs1159057 is in complete LD with rs12507286.
LD, linkage disequilibrium; MAF, minor allele frequency; SNP, single nucleotide polymorphism.