Table 2

Fine mapping of kindred I, chromosome 8 linked region

Marker informationPositionRecombination fraction
Genetic* (cM)Physical (Mb)00.010.050.10.20.30.4
D8S55021.3310 918 926−3.10.72.02.21.91.10.5
D8S55226.4312 752 4484.74.84.84.33.21.90.8
D8S175427.412 999 9603.13.33.33.02.11.20.5
D8S179027.413 076 5013.33.43.33.02.01.10.4
D8S182730.4914 828 7201.24.04.13.82.71.60.6
D8S54931.7315 659 943−2.63.33.63.32.41.50.7
D8S48416 075 5501.74.44.54.12.91.70.7
D8S25434.7616 618 430−0.22.62.92.72.01.30.6
D8S26137.0417 836 4636.76.55.95.13.62.10.9
D8S25841.5520 377 4401.31.31.10.90.50.30.1
D8S28041.5520 437 0632.92.82.52.71.40.80.3
D8S105320 819 0821.81.81.61.40.90.50.2
D8S47421 291 7411.91.91.71.51.00.60.3
D8S111642.8521 440 5681.91.81.61.40.90.50.3
D8S28242.8521 459 0903.23.63.63.12.11.10.3
D8S40521 990 4703.94.24.23.72.61.40.5
D8S173345.4122 542 5152.02.52.72.51.81.10.4
D8S175246.2622 690 0593.84.24.34.02.91.70.6
D8S173422 817 1400.51.11.71.71.30.80.3
D8S13127 395 7480.60.60.50.40.20.10.0
  • Logarithm of odds scores for markers located across the region on chromosome 8p linked to complex hereditary spastic paraparesis in kindred 1. The area flanked by markers D8S550 and D8S131 produced a peak score of 6.7 at marker D8S261 (italic) at θ=0. Boldface numbers indicate scores ≥3.

  • * Sex average marker locations according to Marshfield genetics map. cM, centiMorgan.

  • Physical marker locations obtained from UCSC Human Genome Browser Gateway. Mb, megabase.