Personal and family history | Index cases | Mutations* | |
---|---|---|---|
2010 criteria | Three DGCs in family | 16 | 1 |
met (n=61) | Two DGCs in family, one of them <age 50 | 13 | 5 |
Sporadic DGC<age 40 | 29 | 3 | |
Personal or family history of DGC and LBC, one of the Dx <age 50 | 3 | 2 | |
2010 criteria | Two LBCs<age 50 in case or family | 5 | 3 |
not met (n=104) | Two DGCs in family, both ≥age 50 | 7 | 3 |
Sporadic DGC≥40 | 14 | 1 | |
≥2 LBC, ≤1 of them <age 50 in case or family | 7 | 0 | |
Sporadic unilateral LBC | 14 | 0 | |
Other† | 57 | 0 | |
Total | 165 | 18 |
*Cases are detailed in table 2.
†Consists mainly of cases with a personal and family history of GC/BC with non-diffuse, non-lobular or unknown histology.
DGC, diffuse gastric cancer; Dx, diagnosis of cancer (any type) for the index case; LBC lobular breast cancer.