Observed versus expected number of generalisations of European risk variants to Mexicans by lipid trait
| Generalisation | Directionality | ||||
|---|---|---|---|---|---|
| Trait | #Total tests | #Observed | #Expected* | #Observed | #Expected† |
| TG | 23 | 11 | 12.6 | 20 | 11.5 |
| HDL-C | 38 | 17 | 18.9 | 31 | 19.0 |
| TC | 25 | 14 | 11.3 | 20 | 12.5 |
| LDL-C | 14 | 10 | 8.6 | 12 | 7.0 |
| p Value‡ | 100 | 9.21E-01 | 1.31E-11 | ||
*The expected number of significant associations based on the cumulative power of all loci. Power calculations were performed using Quanto49 with an additive genetic model; the reported effect size from the European GWA meta-analysis7; the sample size and MAF of the Mexican study sample (see online supplementary table S6); as well as the trait mean and SD based on a Mexican population cross-sectional cohort.44
†The expected number of consistent directions of effect by chance (probability=0.5).
‡One-sample binomial test for the difference between the observed and the expected value.
GWA, genome-wide association; HDLC, high-density lipoprotein cholesterol; TG, triglyceride.