Table 2

Discriminative value AUROCa (CI 95%) for models including different covariates and genetic effects, and integrated discrimination improvement (IDI) due to addition of genetic effects to the covariate model

Cov-effectNoneCovariates*
Gen-effectAUROC (95% CI)IDI (%)AUROC (95% CI)IDI (%)
None0.5†0.564 (0.547 to 0.581)
32 SNPs0.583 (0.567 to 0.600)0.160.604 (0.588 to 0.621)0.17
18 SNPs‡0.584 (0.567 to 0.600)0.150.605 (0.589 to 0.622)0.16
9 SNPs0.569 (0.552 to 0.586)0.110.595 (0.579 to 0.612)0.12
7 SNPs0.564 (0.547 to 0.581)0.100.591 (0.574 to 0.608)0.10
  • *Including parameters on age at menarche, at first birth and at menopause and count of births, body mass index (BMI), alcohol consumption, smoking and use of hormone replacement therapy.

  • †*By construction.

  • ‡Better than 32 SNPs according to Akaike information criterion.

  • SNPs, single nucleotide polymorphisms.