Association with extrapulmonary and pulmonary injury-related ARDS in Stage I (p≤0.0005)
| Chr | SNP | Gene | Location | Minor allele | MAF Case/Ctrl. | HWE | OR (95% CI) | p* (additive) |
|---|---|---|---|---|---|---|---|---|
| SNPs associated with extrapulmonary injury-related ARDS | ||||||||
| 19 | rs198977 | KLK2 | Exon | T | 0.34/0.22 | 0.25 | 1.74 (1.23 to 2.32) | 0.00021 |
| 12 | rs9645765 | VWF | Intron | G | 0.14/0.07 | 1 | 2.17 (1.43 to 3.28) | 0.000276 |
| 19 | rs2889490 | SFRS16 | Intron | G | 0.58/0.46 | 0.71 | 1.67 (1.26 to 2.19) | 0.000276 |
| 1 | rs3128126 | ISG15 | Intron | G | 0.48/0.36 | 0.032 | 1.70 (1.28 to 2.26) | 0.000278 |
| 22 | rs16980496 | ADRBK2 | Intron | A | 0.13/0.06 | 0.75 | 2.23 (1.44 to 3.45) | 0.00034 |
| 12 | rs2070887 | VWF | Intron | G | 0.15/0.08 | 0.44 | 2.07 (1.38 to 3.10) | 0.0004 |
| 2 | rs10490072 | BCL11A | 3′ near gene | C | 0.30/0.21 | 0.65 | 1.72 (1.27 to 2.33) | 0.000476 |
| 1 | rs324420 | FAAH | Exon | A | 0.29/0.19 | 0.13 | 1.74 (1.27 to 2.39) | 0.000503 |
| SNPs associated with pulmonary injury-related ARDS | ||||||||
| 7 | rs7807769 | PRKAG2 | Intron | A | 0.48/0.39 | 0.37 | 1.58 (1.28 to 1.94) | 1.61E-05 |
| 7 | rs7801616 | PRKAG2 | Intron | T | 0.48/0.39 | 0.33 | 1.54 (1.25 to 1.89) | 4.37E-05 |
| 6 | rs1190286 | POPDC3 | Intron | C | 0.13/0.20 | 0.29 | 0.53 (0.39 to 0.72) | 5.30E-05 |
| 18 | rs9960450 | TNFRSF11A | Intron | C | 0.08/0.03 | 0.38 | 2.48 (1.56 to 3.93) | 0.000114 |
| 1 | rs2254358 | HSPG2 | Exon | C | 0.25/0.33 | 0.63 | 0.63 (0.50 to 080) | 0.000129 |
| 13 | rs732821 | HTR2A | 5′near gene | A | 0.54/0.45 | 1 | 1.52 (1.22 to 1.88) | 0.000136 |
| 7 | rs6970522 | PRKAG2 | Intron | G | 0.51/0.44 | 0.26 | 1.49 (1.21 to 1.82) | 0.000167 |
| 16 | rs3887893 | ABCC1 | Intron | G | 0.45/0.36 | 0.07 | 1.48 (1.20 to 1.83) | 0.000287 |
| 18 | rs17069902 | TNFRSF11A | Intron | T | 0.09/0.04 | 0.05 | 2.12 (1.41 to 3.20) | 0.000312 |
| 2 | rs2671222 | IL8RA | 5′near gene | A | 0.02/0.06 | 1 | 0.34 (0.19 to 0.61) | 0.000325 |
| 1 | rs12080701 | PDE4B | Intron | G | 0.14/0.09 | 0.30 | 1.85 (1.32 to 2.60) | 0.000362 |
| 19 | rs8112223 | HAS1 | 5′near gene | A | 0.45/0.36 | 0.78 | 1.48 (1.19 to 1.84) | 0.00037 |
| 5 | rs6451620 | GHR | Intron | A | 0.09/0.04 | 0.32 | 2.15 (1.41 to 3.29) | 0.000372 |
| 1 | rs17419964 | PDE4B | Intron | G | 0.34/0.26 | 0.83 | 1.50 (1.20 to 1.88) | 0.000433 |
| 7 | rs802440 | GRM3 | Intron | T | 0.40/0.30 | 0.11 | 1.47 (1.19 to 1.83) | 0.000452 |
| 1 | rs4075731 | MAP3K6 | Intron | A | 0.32/0.40 | 1 | 0.67 (0.54 to 0.84) | 0.000468 |
| 2 | rs2854386 | IL8RA | 3′near gene | C | 0.03/0.07 | 1 | 0.36 (0.20 to 0.64) | 0.000476 |
*p Values were adjusted for age, gender and APACHE III score in Stage I population.
ARDS, acute respiratory distress syndrome; Chr, chromosome; HWE, Hardy–Weinberg equilibrium; MAF, minor allele frequency; SNP, single nucleotide polymorphism.