Table 4

Association results for SNPs significantly associated with pulmonary/extrapulmonary injury-related ALI/ARDS in meta-analysis

SNP	Gene	Chr	Minor allele	Discovery phase (Stage I)				Replication phase I (Stage II)				Replication phase II (Stage III)				Meta-analysis
SNP	Gene	Chr	Minor allele	MAF Case Ctrl	OR	95% CI	p	MAF Case Ctrl	OR	95% CI	p	MAF Case Ctrl	OR	95% CI	p	OR	P-meta	Q*
SNPs significantly associated with extrapulmonary injury-related ALI/ARDS
rs324420	FAAH	1	A	0.29	1.74	(1.27 to 2.39)	0.000503	0.23	1.59	(1.10 to 2.31)	0.0131	0.24	1.85	(1.08 to 3.19)	0.026	1.70	2×10⁻⁶	0.89
rs324420	FAAH	1	A	0.19	1.74	(1.27 to 2.39)	0.000503	0.16	1.59	(1.10 to 2.31)	0.0131	0.17	1.85	(1.08 to 3.19)	0.026	1.70	2×10⁻⁶	0.89
SNPs significantly associated with pulmonary injury-related ALI/ARDS
rs12080701	PDE4B	1	G	0.14	1.85	(1.32 to 2.60)	0.000362	0.09	1.27	(0.81 to 1.98)	0.2997	–	–	–	–	1.61	0.0005	0.19
rs12080701	PDE4B	1	G	0.09	1.85	(1.32 to 2.60)	0.000362	0.09	1.27	(0.81 to 1.98)	0.2997	–	–	–	–	1.61	0.0005	0.19
rs17419964	PDE4B	1	G	0.34	1.50	(1.20 to 1.88)	0.000433	0.25	1.24	(0.94 to 1.62)	0.12	–	–	–	–	1.39	0.0002	0.29
rs17419964	PDE4B	1	G	0.26	1.50	(1.20 to 1.88)	0.000433	0.27	1.24	(0.94 to 1.62)	0.12	–	–	–	–	1.39	0.0002	0.29
rs1190286	POPDC3	6	C	0.13	0.53	(0.39 to 0.72)	5.30E-05	0.14	0.65	(0.46 to 0.90)	0.0094	–	–	–	–	0.58	2.7×10⁻⁶	0.38
rs1190286	POPDC3	6	C	0.20	0.53	(0.39 to 0.72)	5.30E-05	0.20	0.65	(0.46 to 0.90)	0.0094	–	–	–	–	0.58	2.7×10⁻⁶	0.38
rs3887893	ABCC1	16	G	0.45	1.48	(1.20 to 1.83)	0.000287	0.39	1.23	(0.97 to 1.58)	0.0912	–	–	–	–	1.37	0.0001	0.16
rs3887893	ABCC1	16	G	0.36	1.48	(1.20 to 1.83)	0.000287	0.36	1.23	(0.97 to 1.58)	0.0912	–	–	–	–	1.37	0.0001	0.16
rs9960450	TNFRSF11A	18	C	0.08	2.48	(1.56 to 3.93)	0.000114	0.05	1.64	(0.91 to 3.00)	0.1009	–	–	–	–	2.12	5.3×10⁻⁵	0.28
rs9960450	TNFRSF11A	18	C	0.03	2.48	(1.56 to 3.93)	0.000114	0.03	1.64	(0.91 to 3.00)	0.1009	–	–	–	–	2.12	5.3×10⁻⁵	0.28
rs17069902	TNFRSF11A	18	T	0.09	2.12	(1.41 to 3.20)	0.000312	0.06	1.51	(0.91 to 2.50)	0.1098	–	–	–	–	1.85	0.0001	0.31
rs17069902	TNFRSF11A	18	T	0.04	2.12	(1.41 to 3.20)	0.000312	0.04	1.51	(0.91 to 2.50)	0.1098	–	–	–	–	1.85	0.0001	0.31

The meta-analysis was performed using a fixed effects-model (p>0.1 for Cochran's Q test); ARDS, acute respiratory distress syndrome; Case/Ctrl, Case/Controls.Chr, chromosome; MAF, minor allele frequency; SNP, single nucleotide polymorphism.