Patient groups | C9ORF72 | SOD1 | TARDBP | FUS | Other FALS |
Age at onset (years) | |||||
Mean (SE) | 58 (1) | 51 (2) | 52 (3) | 43 (2) | 60 (2) |
Median | 57 | 51 | 57 | 40 | 61 |
Range | 30–81 (n=120) | 21–73 (n=46) | 27–78 (n=18) | 25–68 (n=36) | 32–85 (n=70) |
Disease duration (months)* | |||||
Mean (SE) | 33 (2) | 81 (12) | 56 (8) | 34 (4) | 66 (12) |
Median | 29 | 49 | 48 | 28 | 39 |
Range | 3–85 (n=112) | 4–252 (n=44) | 20–156 (n=18) | 9–88 (n=32) | 8–336 (n=58) |
Bulbar onset† | |||||
Ratio of patients | 48/120 | 3/41 | 2/18 | 5/35 | 14/69 |
FTD‡ | |||||
Ratio of patients | 27/67 | 0/27 | 2/18 | 1/20 | 5/30 |
Gender | |||||
M:F ratio | 1.5:1 (n=130) | 2.1:1 (n=81) | 1.2:1 (n=56) | 1:1.7 (n=27) | 1.1:1 (n=40) |
↵* Disease duration data included censored data (11 for C9ORF72, 8 for SOD1, 1 for TARDBP, 1 for FUS and 11 for other FALS).
↵† The fraction represents the number of patients with bulbar onset/the total number of patients for whom site of onset information was available.
↵‡ The fraction represents the number of patients with frontotemporal dementia (FTD)/the total number of patients who were examined for cognitive deficits.
n, number of patients with the information available.