Association study of the different Tag-SNPs with multiple sclerosis
| SNP | Alleles | Multiple sclerosis | Healthy controls | Allelic p value | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 11 | 12 | 22 | 11 | 12 | 22 | Uncorrected | Benjamini-Hochberg Adjusted | Per allele OR (95% CI) | |
| rs1678542 | C | G | 248 (9) | 1149 (41.7) | 1361 (49.3) | 318 (11.2) | 1229 (43.3) | 1291 (45.5) | 0.0005 | 0.0017 | 0.87 (0.8 to 0.94) |
| rs2888334 | C | G | 134 (4.7) | 946 (33.2) | 1770 (62.1) | 166 (5.7) | 1030 (36.9) | 1676 (58.4) | 0.002 | 0.004 | 0.87 (0.8 to 0.95) |
| rs775249 | T | C | 181 (6.4) | 1047 (36.8) | 1619 (56.9) | 181 (6.3) | 1100 (38.2) | 1601 (55.5) | 0.44 | 0.51 | 0.97 (0.89 to 1.05) |
| rs1678536 | G | C | 129 (4.5) | 922 (32.4) | 1796 (63.1) | 163 (5.7) | 1013 (35.2) | 1701 (59.1) | 0.001 | 0.0023 | 0.86 (0.79 to 0.94) |
| rs7313599 | G | A | 752 (26.4) | 1399 (49.1) | 696 (24.5) | 660 (23) | 1430 (49.7) | 784 (27.3) | 0.0008 | 0.0021 | 1.13 (1.05 to 1.22) |
| rs1078109 | A | G | 6 (0.2) | 366 (12.9) | 2472 (86.9) | 8 (0.28) | 306 (10.6) | 2568 (89.1) | 0.018 | 0.026 | 1.2 (1.03 to 1.4) |
| rs7305391 | A | G | 128 (4.5) | 908 (31.9) | 1813 (63.6) | 119 (4.1) | 967 (33.6) | 1792 (62.3) | 0.5 | 0.537 | 0.97 (0.89 to 1.06) |
| rs1564374 | G | A | 477 (17.2) | 1383 (49.9) | 909 (32.8) | 570 (20.9) | 1349 (49.4) | 812 (29.7) | 0.00037 | 0.0015 | 0.87 (0.81 to 0.94) |
| rs11172290 | G | A | 58 (2) | 735 (25.8) | 2052 (72.1) | 73 (2.5) | 726 (25.2) | 2082 (72.2) | 0.79 | 0.79 | 0.99 (0.89 to 1.09) |
| rs3825078 | A | T | 176 (6.2) | 1115 (39.1) | 1558 (54.7) | 238 (8.2) | 1149 (40) | 1497 (51.9) | 0.003 | 0.006 | 0.88 (0.81 to 0.96) |
| rs701006 | A | G | 222 (7.8) | 1225 (43) | 1403 (49.2) | 318 (11) | 1266 (44) | 1295 (45) | 0.000014 | 0.00008 | 0.84 (0.78 to 0.91) |
| rs2301551 | G | C | 76 (2.7) | 867 (30.5) | 1897 (66.8) | 130 (4.5) | 967 (33.7) | 1769 (61.7) | 3.22E−6 | 0.00003 | 0.8 (0.73 to 0.88) |
| rs12307841 | C | T | 26 (0.9) | 518 (18.1) | 2311 (80.9) | 28 (0.97) | 469 (16.3) | 2386 (82.7) | 0.1097 | 0.15 | 1.11 (0.98 to 1.25) |
| rs12368653 | G | A | 430 (15.1) | 1403 (49.2) | 1016 (35.7) | 502 (17.5) | 1413 (49.2) | 955 (33.3) | 0.009 | 0.015 | 0.91 (0.84 to 0.98) |
| rs1048691 | T | C | 135 (4.8) | 958 (33.8) | 1738 (61.4) | 127 (4.4) | 940 (32.7) | 1805 (62.8) | 0.24 | 0.29 | 1.06 (0.96 to 1.15) |
| rs6581155 | G | A | 110 (4) | 909 (32.7) | 1757 (63.3) | 173 (6.2) | 1002 (36.2) | 1596 (57.6) | 4.57E−7 | 7.3E−6 | 0.79 (0.73 to 0.87) |
Counts (percentages in brackets) are represented for each genotype.