Analysis of family history scores
| Group | Number of families* | Mean BOADICEA score† | Z-scores‡ | |
|---|---|---|---|---|
| Mean | SE | |||
| BRCA-X | 243 | 0.085 | 0.0 | 0.06 |
| R1699Q | 67 | 0.12 | 0.48 | 0.14 |
| R1699W | 34 | 0.36 | 1.81 | 0.20 |
| H0: Q=0 | t=3.51, 66 df, p=0.0004 | |||
| H0: Q=W | t=−5.5, 99 df, p=1.3×10−7 | |||
*Analysis includes 67 families in which the proband carried a R1699Q variant and for which there was at least one matching BRCA-X family, and the 34 matching families in which the proband had a R1699W variant. One R1699Q family was excluded because there was no BRCA-X family available for comparison. For another R1699Q family with only a single matched BRCA-X family, the SD could not be determined, so the average SD across all centres was used for analysis. Families were matched by country, as shown in table 1.
†All BOADICEA scores represent ‘pre-test’ calculations based on family history information only. Score ranges were as follows: Q: 0.0006 to 0.88; W: 0.0026 to 0.97; X: 0.0002 to 0.92.
‡See text for definition of Z-scores.