Table 2

Analysis of family history scores

GroupNumber of families*Mean BOADICEA score†Z-scores‡
H0: Q=0t=3.51, 66 df, p=0.0004
H0: Q=Wt=−5.5, 99 df, p=1.3×10−7
  • *Analysis includes 67 families in which the proband carried a R1699Q variant and for which there was at least one matching BRCA-X family, and the 34 matching families in which the proband had a R1699W variant. One R1699Q family was excluded because there was no BRCA-X family available for comparison. For another R1699Q family with only a single matched BRCA-X family, the SD could not be determined, so the average SD across all centres was used for analysis. Families were matched by country, as shown in table 1.

  • †All BOADICEA scores represent ‘pre-test’ calculations based on family history information only. Score ranges were as follows: Q: 0.0006 to 0.88; W: 0.0026 to 0.97; X: 0.0002 to 0.92.

  • ‡See text for definition of Z-scores.