Evidence that the association between rs6983267 and thyroid cancer risk is best explained by a recessive model
| Test | UK only | Meta analysis of UK and Polish studies | ||
| OR (95% CI) | p Value | OR (95% CI) | p Value | |
| GG vs (GT + TT) | 1.266 (1.071 to 1.494) | 0.004 | 1.250 (1.089 to 1.435) | 7.64×10−4 |
| GG vs GT | 1.262 (1.055 to 1.509) | 0.009 | 1.215 (1.051 to 1.404) | 0.004 |
| GT vs TT | 1.010 (0.827 to 1.236) | 0.960 | 1.087 (0.933 to 1.266) | 0.142 |
Note that the risk allele homozygotes (GG) have significantly higher frequency compared with other genotypes combined (GT + TT) and with heterozygotes (GT). This is also the case for the GG versus TT test which is not shown. However, there is no evidence that heterozygotes are over-represented in cases (GT vs TT).