Table 1

Summary frequencies of tumour BRAF V600E mutation status

Sample group	Number of studies	Positive BRAF V600E	Negative BRAF V600E	BRAF V600E frequency^* (95% CI)
Known negative MMR mutation status
MSI-H known negative mutation status	11	115	216	36.10% (20.95% to 52.84%)
MLH1 methylation OR MLH1 immunoloss (known or assumed MSI-H status)	9	191	141	63.50% (46.98% to 78.53%)
MSS	11	85	1538	5.00% (3.55% to 6.68%)
Known positive MMR mutation status
All mutation carriers^†	26	4	546	1.40% (0.06% to 2.52%)

↵* Calculated by meta-analysis, as described in the methods section.
↵† 1/4 BRAF-positive tumours was from an MLH1 mutation carrier, 185/546 BRAF negative tumours were from MLH1 mutation carriers.