Basic model | p Value of covariates | ||||||||||
Trait | H2 | p | Sex | Age | Age2 | Sex*age | Sex*age2 | Ft | Hep | Tf Sat | Effect of covariates |
Log10(hepcidin) | 0.098 | NS | ** | NS | NS | **** | ** | ND | ND | ND | 0.045 |
Log10(hepcidin)† | 0.080 | NS | NS | NS | NS | **** | **** | **** | ND | NS | 0.139 |
Log10(hepcidin/ferritin)‡ | 0.219 | *** | **** | NS | NS | *** | **** | ND | ND | NS | 0.117 |
Log10(ferritin) | 0.455 | **** | **** | **** | * | NS | NS | ND | ND | ND | 0.225 |
Log10(ferritin)§ | 0.381 | **** | **** | NS | NS | NS | NS | ND | **** | ND | 0.299 |
Log10(ferritin)¶ | 0.362 | **** | **** | **** | **** | NS | * | ND | **** | NS | 0.399 |
*p<0.05; **p<0.01; ***p<0.001;****p<0.0005.
All models included sex, age, age2, sex*age, sex*age2 as covariates.
H2: Heritability corresponding to the genetic component of the variability of each trait; age2: squared age; sex*age: interaction between sex and age; sex*age2: interaction between sex and squared age.
† Ferritin, Tf Sat,Tf, Iron, MCH, MCHC, MCV, Hb, Hct were also included in the model. The only covariates significant (p<0.01) were iron and ferritin (p<0.0005).
‡ This model included also all the variables but ferritin.
§ This model included also hepcidin as covariate.
¶ This model included also hepcidin, Tf Sat,Tf, Iron, MCH, MCHC, MCV, Hb and Hct.
Ft, ferritin; Hb, haemoglobin; Hct, haematocrit; Hep, hepcidin; MCH, mean corpuscular haemoglobin; MCHC mean corpuscular haemoglobin concentration; MCV, mean corpuscular volume; ND, not done; Tf Sat, transferrin saturation.