Table 2

Association results

Power GER/GR	Gene	SNP	GER				GR				Combined analysis
Power GER/GR	Gene	SNP	MAF (Ca/Co)	P_nom	P_corrected	OR (95% CI)	MAF (Ca/Co)	P_nom	P_corrected	OR (95% CI)	P_nom	P_corrected	OR (95%)
98%/95%	MEIS1	rs6710341	0.17/0.14	0.282	0.877	1.2 (0.86 to 1.66)	0.15/0.18	0.242	0.911	0.79 (0.54 to 1.17)	0.891	1	1.02 (0.80 to 1.30)
		rs12469063	0.31/0.23	0.002	0.013	1.52 (1.17 to 1.98)	0.23/0.26	0.305	0.961	0.84 (0.60 to 1.17)	0.086	0.421	1.20 (0.97 to 1.47)
		rs2300478	0.31/0.24	0.004	0.026	1.47 (1.13 to 1.92)	0.23/0.25	0.355	0.979	0.86 (0.62 to 1.19)	0.110	0.512	1.18 (0.96 to 1.45)
85%/74%	BTBD9	rs3923809	0.25/0.34	0.001	0.009	1.55 (1.19 to 2.04)	0.28/0.36	0.080	0.525	1.33 (0.97 to 1.82)	0.0002	0.0013	1.47 (1.20 to 1.79)
76%/65%	MAP2K5/SKOR1	rs11635424	0.31/0.34	0.168	0.677	1.2 (0.93 to 1.56)	0.34/0.39	0.115	0.659	1.26 (0.95 to 1.68)	0.040	0.235	1.22 (1.01 to 1.48)
		rs3784709	0.31/0.35	0.238	0.814	1.17 (0.90 to 1.52)	0.34/0.38	0.021	0.175	1.41 (1.05 to 1.90)	0.017	0.106	1.27 (1.04 to 1.54)
		rs1026732	0.30/0.34	0.294	0.889	1.15 (0.89 to 1.50)	0.31/0.38	0.069	0.467	1.31 (0.98 to 1.74)	0.049	0.280	1.21 (1.00 to 1.47)
		rs6494696	0.31/0.34	0.259	0.846	1.16 (0.9 to 1.51)	0.34/0.39	0.069	0.467	1.31 (0.98 to 1.74)	0.043	0.240	1.22 (1.01 to 1.48)
69%/56%	PTPRD	rs1975197	0.15/0.18	0.278	0.871	0.84 (0.61 to 1.15)	0.16/0.18	0.781	1	0.95 (0.66 to 1.37)	0.273	0.876	0.87 (0.68 to 1.11)
69%/56%	PTPRD	rs4626664	0.14/0.13	0.687	1	1.08 (0.75 to 1.54)	0.08/0.09	0.856	1	1.05 (0.64 to 1.71)	0.713	1	1.06 (0.79 to 1.41)

Loci are ordered according to the power of the study to detect the effects, based on allele frequencies and ORs found in previous studies.7 8 11
Ca, cases; Co, controls; MAF, minor allele frequency; P_nom, nominal p value from logistic regression analysis with age and gender as covariates. For the combined analysis, country of origin was added as an additional covariate. P_corrected, p value corrected for multiple testing, empirical p value obtained from permutation.
ORs were obtained from logistic regression analysis and refer to the risk allele. Significant associations are highlighted in bold print.