Classical Li–Fraumeni syndrome (LFS) criteria

Li et al3

A proband with sarcoma diagnosed under the age of 45 years

AND

A first degree relative with any cancer under 45 years

AND

Li–Fraumeni-like syndrome (LFL) criteria

Birch et al4

A proband with any childhood cancer or sarcoma, brain tumour or adrenal cortical tumour under the age of 45 years

AND

A first or second degree relative with a typical LFS cancer at any age

AND

LFL criteria

Eeles5

LFS Chompret criteria

Chompret et al6

A proband affected by a narrow spectrum cancer (sarcomas, brain tumours, breast cancer and adrenal cortical carcinoma) before 36 years

and at least one first or second degree relative affected by a narrow spectrum tumour (other then breast cancer if the proband is affected by breast cancer) before 46 years or multiple primary tumours

OR

A proband with multiple primary tumours two of which belong to the narrow spectrum and the first of which occurred before 36 years

OR

LFS Chompret criteria revised

Tinat et al7

A proband with a tumour belonging to the LFS tumour spectrum (soft tissue sarcoma, osteosarcoma, brain tumours, pre-menopausal breast cancer, adrenal cortical carcinoma, leukaemia, lung bronchoalveolar cancer) before 46 years

and at least one first or second degree relative with an LFS tumour (except breast cancer if the proband is affected by breast cancer) before 56 years or multiple primary tumours

OR

A proband with multiple primary tumours (except multiple breast tumours), two of which belong to the LFS tumour spectrum and the first of which occurred before 46 years

OR