Table 1

Analysis by transmission disequilibrium testing of eight single nucleotide polymorphisms (SNPs) within the 1-LOD drop interval defining the Chr 13q linkage region significant at p<0.01 from the genome-wide association study (GWAS)

SNPChr bandPositionGeneGWAS studyGWAS study + all remaining samples*
CasesControlsp ValueORp ValueOR95% CI
rs732037513q32.194709934ABCC40.0580.0200.00592.970.0000882.001.41 to 2.83
rs798608713q32.194713746ABCC40.0540.0200.00622.740.00031.981.38 to 2.83
rs1107014613q32.195098788DZIP10.1160.0510.00152.450.041.251.01 to 1.55
rs1107014713q32.195098938DZIP10.1170.0510.00142.470.071.220.99 to 1.51
rs28503213q32.197584534FARP10.430.590.00040.520.530.960.84 to 1.10
rs951351513q32.398394451DOCK90.4710.4080.00231.300.201.100.95 to 1.27
rs955709613q32.398401880DOCK90.4710.4090.00311.290.091.130.98 to 1.30
rs477236013q33.11.01E+08VGCNL10.1160.1350.00800.840.180.890.75 to 1.06
  • * 1177 KD subjects and associated family members, total=3010 subjects.