Patient groups | SOD1 | TARDBP | FUS | Other FALS |

M:F ratio | 1.2:1 (n=55) | 1:1.87 (n=23) | 1.23:1 (n=29) | 2:1 (n=126) |

Age at onset (years) | ||||

Mean | 55 (SE 2, n=38) | 54 (SE 4, n=17) | 45 (SE 3, n=23) | 58 (SE 1, n=115) |

Median | 55 (SE 2, n=38) | 58 (SE 5, n=17) | 47 (SE 7, n=23) | 58 (SE 2, n=115) |

Cox regression test^{*} | p=0.004 | |||

Disease duration (months)^{†} | ||||

Mean | 79 (SE 14, n=38) | 58 (SE 9, n=17) | 30 (SE 4, n=23) | 45 (SE 5, n=100) |

Median | 36 (SE 10, n=38) | 51 (SE 9, n=17) | 26 (SE 3, n=23) | 32 (SE 2, n=100) |

Cox regression test^{*} | p=0.005 | |||

Lifespan (years)^{†} | ||||

Mean | 59 (SE 2, n=45) | 59 (SE 4, n=21) | 46 (SE 2, n=29) | 61 (SE 1, n=101) |

Median | 59 (SE 2, n=45) | 60 (SE 5, n=21) | 45 (SE 6, n=29) | 59 (SE 2, n=101) |

Cox regression test^{*} | p<0.0001 | |||

Mean bulbar score^{‡} | 3.7 (SE 1, n=13) | 11.7 (SE 3.2, n=7) | 3.6 (SE 0.7, n=9) | 9.3 (SE 1.4, n=50) |

ANOVA | p=0.0454 | |||

Cognitive impairments^{§} | 0/20 | 2/10 | 1/13 | 10/62 |

↵* Equality of survival distribution between

*SOD1*,*TARDBP*,*FUS*and other familial amyotrophic lateral sclerosis (FALS) groups was analysed using a Cox regression test. If the difference was significant p<0.05, the groups were compared by pairs using a log rank test.↵† Disease duration and age at death data included censored data (8 for

*SOD1*, 2 for*TARDBP*, 2 for*FUS*, and 11 for other FALS).↵‡ The difference between initial (at onset) and final (at the end of the disease) bulbar Norris scale (13 items) was recorded for each patient. Means were compared using one way analysis of variance (ANOVA).

↵§ The fraction represents the number of patients with cognitive impairment/total number of patients who were examined for cognitive deficits.

n, number of patients for whom the information was available; NA, data not available.