Table 3

Details of FLCN mutation status and immunohistochemical status of mismatch repair proteins, in the MSI+ colorectal tumour DNA samples analysed, where information was available

TumourFolliculinMSIImmunohistochemical analysis
1No mutation4 of 4 (3/3BATs)Loss of MLH1
2No mutation4 of 4 (3/3BATs)NA
3No mutation2 of 4 (1/3BATs)No loss of MLH1/MSH2
4Mutation7 of 7 (3/3BATs)Loss of MLH1
5No mutation6 of 6 (3/3BATs)NA
6No mutation2 of 7 (0/3BATs)No loss of MLH1/MSH2/MSH6/PMS2
7No mutation3 of 7 (2/3BATs)No loss of MLH1/MSH2/MSH6
8No mutation2 of 7 (0/3BATs)No loss of MLH1/MSH2
9No mutation4 of 4 (0/0BATs)Loss of MLH1
10Mutation4 of 5 (2/2BATs)Loss of MLH1/PMS2
11No mutation3 of 6 (2/2BATs)No loss of MLH1/MSH2
12No mutation2 of 7 (0/3BATs)No loss of MLH1/MSH2
13No mutation3 of 7 (3/3BATs)No loss of MLH1/MSH2
14Mutation7 of 7 (3/3BATs)Loss of MSH2
15No mutation7 of 7 (3/3BATs)Loss of MLH1
16No mutation3 of 7 (3/3BATs)Loss of MLH1
17No mutation4 of 6 (3/3BATs)NA
18No mutation2 of 4 (1/3BATs)No loss of MLH1/MSH2
19No mutation3 of 7 (0/3BATs)No loss of MLH1/MSH2
20No mutation6 of 7 (3/3BATs)Loss of MLH1
21No mutation7 of 7 (3/3BATs)No loss of MLH/MSH2
22No mutation3 of 7 (3/3BATs)No loss of MLH1/MSH2
23Mutation3 of 6 (0/3BATs)NA
24No mutation5 of 7 (1/3BATs)Loss of MSH2
25Mutation5 of 7 (2/3BATs)Loss of MLH1
26No mutation2 of 7 (2/3BATs)No loss of MLH1/MSH2
27No mutation7 of 7 (3/3BATs)Loss of MLH1/PMS2
28MutationUnknownLoss of MLH1/PMS2
29Mutation7 of 7 (3/3BATs)Loss of MLH1
30No mutation5 of 7 (3/3BATs)Loss of MSH2