Table 1

Association of the SNPs and hand OA in the discovery samples

SNP	Chr	position	Minor allele	TwinsUK cohort			Rotterdam discovery subset
SNP	Chr	position	Minor allele	MAF	β (SE)	p Value†	MAF	β* (SE)	p Value
rs1334995	1	70839082	A	0.18	−0.27 (0.07)	2.3×10⁻⁴	0.19	−0.12 (0.06)	0.05
rs2443547	5	18209429	G	0.46	0.20 (0.06)	3.6×10⁻⁴	0.49	−0.11 (0.46)	0.02
rs1958654	14	5329267	T	0.14	0.30 (0.08)	2.4×10⁻⁴	0.13	−0.13 (0.07)	0.05
rs938076	15	23784012	A	0.46	0.22 (0.05)	3.7×10⁻⁵	0.48	−0.01 (0.04)	0.01
rs716508	16	6276913	C	0.31	−0.24 (0.06)	6.4×10⁻⁵	0.33	0.10 (0.05)	0.04

β, regression coefficient; Chr, chromosome; MAF, minor allele frequency; SNP, single-nucleotide polymorphism
*Expressed as changes in total KL score per copy of the risk allele after adjustment for age
†Not Bonferroni corrected but adjusted for the relatedness in the TwinsUK cohort.