Table 1

Denominators used to calculate prevalence of findings in individuals with intragenic sequence determined mutations in ZIC2

	Probands	All affected individuals^*
Total patients	103	141
Gender	90	127
Holoprosencephaly (HPE) type	86	105
Structural neurological findings^†	81	92
Inheritance	65	85
Extra-neurological findings	64	76
Facial phenotype^‡	59	59