MtDNA mutation | In vitro88 235–249 | In vivo63–67 | ||
Complex I activity (%) | Respiratory rate (%) | ATP synthesis (%) | 31P MRS (%) | |
m.3460G>A | 60–80 | 30–35 | 90 | 0–40 |
m.11778G>A | 0–50 | 30–50 | 35 | 75 |
m.14484T>C | 0–65 | 10–20 | 90 | 50 |
ATP, adenosine triphosphate; 31P-MRS, phosphorus magnetic resonance spectroscopy.
% decrease relative to controls.