Table 1 Pathogenic mtDNA mutations associated with Leber hereditary optic neuropathy

	Mutation	Gene	Prevalence (%)	Reference
Primary			>95
	m.3460G>A	MT-ND1	13	220, 221
	m.11778G>A	MT-ND4	69	7
	m.14484T>C	MT-ND6	14	32, 222
Rare			<5
	m.3376G>A	MT-ND1		45
	m.3697G>A			46
	m.3733G>A			223
	m.4160T>C			41
	m.4171C>A			224
	m.11696G>A	MT-ND4		40
	m.11253T>C			225
	m.10663T>C	MT-ND4L		226
	m.12848C>T	MT-ND5		227
	m.13730G>A			228
	m.14568C>T	MT-ND6		229
	m.14279G>A			230
	m.14459G>A			42–44
	m.14482C>G			231
	m.14495A>G			232
	m.14498C>T			233
	m.14568C>T			234
	m.14596A>T			40