Table 1 Characteristics and responses of fragile X syndrome subjects treated with single dose fenobam
Study*GenderEthnicityIQConcomitant medications†Fenobam dose (mg)Side effects‡PPI§Type of improvement noted clinically‡
01-001MC53Aripiprazole quetiapine50None+Improved eye contact and interaction
01-002MC55Venlafaxine aripiprazole150None+Improved interaction
01-003FAA/H85Venlafaxine150Mild sedationNo improvement
01-004MC52None150Mild sedationCalmed behaviour, improved eye contact, less perseveration
01-005FC71None150None+Improved interaction
01-006FC66None150Mild sedationCalmed behaviour, less nervous giggling, improved eye contact
02-001MCN/ANone100NoneImproved eye contact
02-002FC54Dextro-amphetamine fluoxetine50None+Calmed behaviour and improved eye contact
02-003FC53Methylphenidate100None+No improvement
02-004MC36Fluoxetine150None+Improved eye contact and interaction
02-005MAA36Dextro-amphetamine150NoneNo improvement
02-006FC50Escitalopram150Anxious, tremulous, clammy. Lightheaded when IV was put inCalmed behaviour, able to tolerate blood draws better, much more tolerant of IV placement
Average (SD)55.5 (13.6)
  • AA, African American; C, Caucasian; F, female; H, Hispanic; IV, intravenous catheter; M, male; N/A, IQ measurements were not available for this subject.

  • *01 = MIND Institute UCDMC; 02 = Rush University Medical Center.

  • †Only psychoactive concomitant medications; 3 subjects on stimulants, 3 on selective serotonin reuptake inhibitors, 2 on other antidepressant, 2 on atypical antipsychotics.

  • ‡Side effects and clinical improvement were characterised by observations at designated time points (0,15, 30, 45, 60, 120, 180, 240, 300, 360 min) by the principal investigator (PI) and by formal questioning of the subject/guardian throughout the visit for the occurrence of central nervous system (CNS) side effects relevant to fenobam from a checklist (see Methods) new, or worsening of existing signs, symptoms or behaviours.

  • §Result of prepulse inhibition (PPI) after fenobam relative to baseline; “+” denotes achieved response criterion of 20% improvement in PPI and “–” represents <20% improvement.