| Analyte tested (reference range) | Men | Women | p Value | ||
| Serum calcium (2.13–2.63 mmol/l) | 2.42 (0.09) | 2.38 (0.10) | 0.075 | ||
| Serum phosphate (0.77–1.50 mmol/l) | 1.03 (0.16) | 1.12 (0.18) | 0.034 | ||
| Serum creatinine (0.5–1.0 mg/dl) | 0.8 (0.1) | 0.7 (0.1) | <0.01 | ||
| Serum alkaline phosphatase (34–104 U/I) | 67.1 (26.8) | 62.9 (18.4) | 0.465 | ||
| Serum bone specific alkaline phosphatase (males: 8.0–16.8 μg/l; females: 7.5–15.7 μg/l) | 11.1 (4.4) | 10.2 (4.8) | 0.188 | ||
| Serum leutenising hormone (males: 1.7–8.6 U/I; females: 1–9.5 U/I) | 6.3 (3.6) | 20.5 (19.2) | <0.01 | ||
| Serum follicle stimulating hormone (males: 1.5–12.4 U/I; females: 1.7–21.5 U/I) | 9.2 (6.4) | 31.9 (39.1) | 0.01 | ||
| Serum oestradiol (males: 13.5–59.0 ng/l; females: 24.5–411 ng/l) | 30.7 (8.9) | 99.9 (119.5) | 0.03 | ||
| Serum osteocalcin (3.1–13.7 μg/l) | 10.2 (5.6) | 9.6 (3.7) | 0.622 | ||
| Serum parathyroid hormone (10–65 ng/l) | 62.4 (35.2) | 58.7 (22.2) | 0.836 | ||
| Serum 25-hydroxy-vitamin D—winter (15.2–17.5 μg/l)* | 10.9 (5.0) | 14.0 (6.5) | 0.053 | ||
| Serum 25-hydroxy-vitamin D—summer (22.0–27.0 μg/l)* | 19.5 (8.4) | 22.4 (7.6) | 0.205 | ||
| Serum 1,25–di-hydroxy-vitamin D (22–46 ng/l) | 36.3 (13.0) | 38.5 (16.7) | 0.535 | ||
| Serum bone TRAP5b (males: 1.5–4.7 U/l; females <50 years old: 1.1–3.9 U/l; females >50 years old: 1.4–4.2 U/l) | 3.5 (1.0) | 3.2 (0.9) | 0.197 | ||
| Urine deoxypyridinoline cross-links (males: 2.3–5.4 nmol/mmol creatinine; females: 3.0–7.4 nmol/mmol creatinine) | 7.1 (4.4) | 7.5 (2.2) | 0.181 | ||
| Urine calcium (3.0–5.0 mmol/24 h) | 4.6 (2.5) | 3.5 (2.1) | 0.059 | ||
| Urine phosphate (10.0–32.0 mmol/24 h) | 24.2 (9.5) | 23.4 (10.2) | 0.536 | ||
| Urine creatinine (0.8–1.5 g/24 h) | 1.4 (0.39) | 1.2 (0.42) | <0.01 | ||
| Creatinine clearance (100–155 ml/min) | 118 (41.6) | 100 (31.7) | 0.05 | ||
| Total hip T score | −1.5 (1.2) | −1.1 (1.0) | 0.126 | ||
| Lumbar spine T score | −1.6 (1.4) | −1.0 (1.3) | 0.088 |
*Values obtained from normal population sampled at time of blood collection for NF1 patients.