Table 1 Association analysis between the RASGRP1 variations and type 1 diabetes

Cohort	Minor allele (frequency)	Hardy–Weinberg p value	Informative family number*	Z (p value)
The T1DGC RR2 cohort
rs17574546	C (0.225)	0.931	302	2.93 (p = 3.41×10⁻³)
The Canadian cohort and extra T1DGC samples†
rs7171171	G (0.207)	0.873	665	3.93 (p = 8.40×10⁻⁵)
Combined analysis	− (0.209)	1.000	967	4.84 (p = 1.30×10⁻⁶)

*Number of families informative for (with a non-zero contribution to) the Family Based Association Test (FBAT) analysis; †no redundant sample with the Type 1 Diabetes Genetics Consortium Rapid Response 2 (T1DGC RR2) cohort.