Table 6

Sensitivity, specificity and positive predictive value of Manchester Scores at 10% and 20% threshold adjusted and not adjusted for pathology and receptor status

SensitivitySpecificityPPVNPV
BRCA1 10 points, unadjusted180/203 (89%)1184/1953 (61%)180/947 (19%)1184/1207 (98%)
BRCA1 10 points, adjusted192/203 (95%)1211/1953 (62%)192/934 (21%)1211/1222 (99%)
Combined 16+ points unadjusted BRCA1192/203 (95%)860/1953 (44%)192/1283 (15%)860/871 (98.7%)
Combined 16+ points adjusted BRCA1196/203 (97%)899/1953 (46%)196/1250 (16%)899/906 (99.2%)
Combined 16+ points unadjusted BRCA1/2361/389 (93%)843/1767 (48%)361/1283 (28%)843/871 (97%)
Combined 16+ points adjusted BRCA1/2365/389 (94%)914/1767 (52%)365/1218 (30%)890/914 (97.5%)
Combined 20+ points unadjusted BRCA1/2319/389 (82%)1211/1767 (70%)319/873 (36.5%)1211/1281 (94.5%)
Combined 20+ points adjusted BRCA1/2328/389 (84%)1280/1767 (74%)328/815 (40%)1280/1341 (95.5%)
  • NPV, negative predictive value; PPV, positive predictive value.