Table 1 Sequence variations found in the TARDBP gene in the 285 sporadic amyotrophic lateral sclerosis cases from France

Exon	Variant	Sex	Age of onset	Site of onset	Conserved	PolyPhen prediction	SIFT prediction
Damaging variants
6	p.G348C	M	55	Bulbar	Yes	Damaging	Intolerant
6	p.G348C	M	48	Bulbar	Yes	Damaging	Intolerant
6	p.G348C	M	46	Spinal	Yes	Damaging	Intolerant
6	p.P363A*	M	61	Spinal	Yes	Damaging	Tolerant
6	p.Y374X*	M	63	Spinal	Yes	n/a	n/a
6	p.A382P*	F	68	Spinal	No	Benign	Tolerant
Benign variants
1	p.A66A	F	70	Bulbar	Yes	Benign	Tolerant
1	p.A66A	F	64	Spinal	Yes	Benign	Tolerant
6	3′utr c.1462 T>C*	F	73	Bulbar	n/a	n/a	n/a

n/a, not available; SIFT, Sorting Intolerant From Tolerant.
*New variants identified in this study.