Prior and adjusted risk for spinal muscular atrophy carrier status when two or three SMN1 copies are detected by quantitative assays
Ethnicity | Prior risk† | Adjusted risk | |
2 copies | 3 copies* | ||
Caucasian | 1:35 | 1:632 | 1:3500 |
Ashkenazi Jewish | 1:41 | 1:350 | 1:4000 |
Asian | 1:53 | 1:628 | 1:5000 |
African American | 1:66 | 1:121 | 1:3000 |
Hispanic | 1:117 | 1:1061 | 1:11000 |
*The risk estimates were rounded to two significant digits due to approximations in their calculations
†Prior risk is the probability of having any carrier genotype (1+0, 1+1D, 2+0 and 2+1D).