Table 3

Frequency of SMN1 allele pairings

Allele pairingsCaucasianAshkenazi JewishAsianAfrican AmericanHispanic
Non-carrier
    2+20.00110.00650.00320.07480.0059
    2+10.06210.14620.10580.39310.1416
    1+10.90810.82300.87200.51690.8439
    Total0.97130.97560.98100.98480.9914
Carrier
    2+1D*1.7E–053.6E–052.0E–057.7E–051.2E–05
    2+00.00090.00190.00110.00410.0007
    1+1D0.00050.00040.00030.00020.0001
    1+00.02720.02200.01750.01080.0078
    Total0.02860.02430.01890.01520.0086
Affected
    1D+1D*7.1E–085.1E–082.0E–083.1E–086.2E–09
    1D+0*7.6E–065.5E–062.1E–063.3E–066.7E–07
    0+02.0E–041.5E–045.7E–058.8E–051.8E–05
    Total2.1E–041.5E–045.9E–059.1E–051.9E–05
  • *These genotype frequency estimates lack precision because of the limited data for the 1D allele frequency.11