Table 5 Mean age of first tumour onset in TP53 mutation carriers, according to the type of TP53 alteration and to the MDM2 SNP309 genotype
MDM2 SNP309 genotypeType of TP53 alteration
MissenseOther
Number of index cases/carriersMean age of first tumour onset (years)Number of index cases/carriersMean age of first tumour onset (years)
T/G+G/G27/3016.2/16.420/2526.8/26.3
T/T20/2727.2/26.36/735.5/38.9

  • The number of index cases and mutation carriers (corresponding to index cases plus mutation carrier relatives) are indicated.