Table 4 Mean age of first tumour onset in TP53 mutation carriers, according to the MDM2 SNP309 genotype

MDM2 SNP309 genotype	Index cases		Carriers
MDM2 SNP309 genotype	Number of patients (n = 73)	Mean age of first tumour onset (years)	Number of patients (n = 89)	Mean age of first tumour onset (years)
T/G+G/G	47	20.7	55	20.9
T/T	26	29.1	34	28.9
		p = 0.012		p = 0.01

The number of index cases and mutation carriers (corresponding to index cases plus mutation carrier relatives) are indicated.