Type of alteration | Index cases | Carriers | ||
Number of patients (n = 84) | Mean age of first tumour onset (years) | Number of patients (n = 116) | Mean age of first tumour onset (years) | |
Missense | 54 | 20.9 | 73 | 22.3 |
Other | 30 | 28.9 | 43 | 31.4 |
p = 0.017 | p = 0.004 |
The number of index cases and mutation carriers (corresponding to index cases plus mutation carrier relatives) are indicated.