Table 3 Mean age of first tumour onset in TP53 mutation carriers, according to the type of TP53 alteration

Type of alteration	Index cases		Carriers
Type of alteration	Number of patients (n = 84)	Mean age of first tumour onset (years)	Number of patients (n = 116)	Mean age of first tumour onset (years)
Missense	54	20.9	73	22.3
Other	30	28.9	43	31.4
		p = 0.017		p = 0.004

The number of index cases and mutation carriers (corresponding to index cases plus mutation carrier relatives) are indicated.