ROC area (95% CI) | |||
BRCA1 and BRCA2 vs non-carriers | BRCA1 vs non-BRCA1 | BRCA2 vs non-BRCA2 | |
BOADICEA | 0.77 (0.74 to 0.80) | 0.82 (0.79 to 0.85) | 0.68 (0.64 to 0.72) |
BRCAPRO* | 0.76 (0.73 to 0.79) | 0.79 (0.76 to 0.82) | 0.68 (0.64 to 0.72) |
Manchester | 0.75 (0.72 to 0.77) | 0.77 (0.73 to 0.80) | 0.68 (0.64 to 0.72) |
IBIS† | 0.74 (0.71 to 0.77) | 0.79 (0.76 to 0.82) | 0.62 (0.57 to 0.67) |
Myriad | 0.72 (0.69 to 0.75) | NA (NA) | NA (NA) |
NA, not available; ROC, receiver operating characteristic.
*Standard implementation. †Based on 1889 observations.