Table 3 Association of breast-cancer risk with the c.-2265C→T SNP in the BRCA1 gene, on participants recruited in the Hong Kong Chinese and in the Shanghai Breast Cancer Study
c.-2265C→THong KongShanghaiTOH,p ValueCombined analysis‡
Cases (%)Controls (%)p Value*OR (95% CI)*Cases (%)Controls (%)p Value†OR 95% CI)†p ValueOR (95% CI)
All participants§
n36837511091185
CC143 (38.9)109 (29.1)1.00 (RV)469 (42.3)457 (38.6)1.00 (RV)1.00 (RV)
CT/TT225 (61.1)266 (70.9)0.0050.64 (0.47 to 0.88)640 (57.7)728 (61.4)0.0540.85 (0.71 to 1.00)0.110.0030.80 (0.69 to 0.93)
HWE p value¶0.230.220.070.55
Participants without a family history of breast cancer
n33336310701156
CC129 (38.7)107 (29.5)1.00 (RV)459 (42.9)442 (38.2)1.00 (RV)1.00 (RV)
CT/TT204 (61.3)256 (70.5)0.010.66 (0.48 to 0.91)611 (57.1)714 (61.8)0.0190.81 (0.69 to 0.97)0.230.0010.78 (0.68 to 0.91)
Participants ⩾45 years at first diagnosis and without a family history of breast cancer
n166166637678
CC71 (42.8)46 (27.7)1.00 (RV)281 (44.1)265 (39.1)1.00 (RV)1.00 (RV)
CT/TT95 (57.2)120 (72.3)0.0060.51 (0.32 to 0.81)356 (55.9)413 (60.9)0.0390.79 (0.63 to 0.99)0.080.0040.75 (0.61 to 0.91)
  • HWE, Hardy–Weinberg equilibrium; RV, reference value; TOH, test of heterogeneity.

  • *p Values were obtained by χ2 square test, df = 1.

  • †Logistic regression analysis adjusted for age, education, body mass index, waist to hip ratio, physical activity, menopausal status, age at menarche and age at first live birth.

  • ‡Combined analysis was performed using Mantel–Hanzel test.

  • §Overall cases and control participants successfully genotyped.

  • ¶p Values for HWE were calculated by χ2 square test, df = 1.