Table 3 Association of breast-cancer risk with the c.-2265C→T SNP in the BRCA1 gene, on participants recruited in the Hong Kong Chinese and in the Shanghai Breast Cancer Study

c.-2265C→T	Hong Kong						Shanghai				TOH,p Value		Combined analysis‡
c.-2265C→T	Cases (%)			Controls (%)	p Value*	OR (95% CI)*	Cases (%)	Controls (%)	p Value†	OR 95% CI)†	TOH,p Value		p Value	OR (95% CI)
All participants§
n	368		375				1109	1185
CC	143 (38.9)		109 (29.1)			1.00 (RV)	469 (42.3)	457 (38.6)		1.00 (RV)				1.00 (RV)
CT/TT	225 (61.1)		266 (70.9)		0.005	0.64 (0.47 to 0.88)	640 (57.7)	728 (61.4)	0.054	0.85 (0.71 to 1.00)		0.11	0.003	0.80 (0.69 to 0.93)
HWE p value¶	0.23		0.22				0.07	0.55
Participants without a family history of breast cancer
n	333		363				1070	1156
CC	129 (38.7)		107 (29.5)			1.00 (RV)	459 (42.9)	442 (38.2)		1.00 (RV)				1.00 (RV)
CT/TT	204 (61.3)		256 (70.5)		0.01	0.66 (0.48 to 0.91)	611 (57.1)	714 (61.8)	0.019	0.81 (0.69 to 0.97)		0.23	0.001	0.78 (0.68 to 0.91)
Participants ⩾45 years at first diagnosis and without a family history of breast cancer
n	166	166					637	678
CC	71 (42.8)	46 (27.7)				1.00 (RV)	281 (44.1)	265 (39.1)		1.00 (RV)				1.00 (RV)
CT/TT	95 (57.2)	120 (72.3)			0.006	0.51 (0.32 to 0.81)	356 (55.9)	413 (60.9)	0.039	0.79 (0.63 to 0.99)		0.08	0.004	0.75 (0.61 to 0.91)

HWE, Hardy–Weinberg equilibrium; RV, reference value; TOH, test of heterogeneity.
*p Values were obtained by χ² square test, df = 1.
†Logistic regression analysis adjusted for age, education, body mass index, waist to hip ratio, physical activity, menopausal status, age at menarche and age at first live birth.
‡Combined analysis was performed using Mantel–Hanzel test.
§Overall cases and control participants successfully genotyped.
¶p Values for HWE were calculated by χ² square test, df = 1.