Table 1 Analysis of BRCA1 promoter polymorphisms c.-2804T→C, c.-2265C→T, c.-2004A→G and c.-1896(ACA)1→(ACA)2) for breast-cancer risk association in Hong Kong Chinese participants
PolymorphismGenotype/alleleCaseControlp ValueOR (95% CI)*
n (%)n (%)
c.-2804T→CTT133 (37.50)112 (30.10)0.094†1.00 (RV)
TC169 (47.60)192 (51.60)0.0710.74 (0.54 to 1.03)
CC53 (14.90)68 (18.30)0.0590.65 (0.42 to 1.02)
TC/CC222 (62.50)260 (69.90)0.0360.72 (0.53 to 0.98)
T allele435 (61.30)416 (55.90)1.00 (RV)
C allele275 (38.70)328 (44.10)0.0380.80 (0.65 to 0.99)
HWE p value‡0.950.37
c.-2265C→TCC143 (38.90)109 (29.10)0.0181.00 (RV)
CT164 (44.60)197 (52.50)0.0060.63 (0.46 to 0.88)
TT61 (16.60)69 (18.40)0.0680.67 (0.44 to 1.03)
CT/TT225 (61.10)266 (70.90)0.0050.64 (0.47 to 0.88)
C allele450 (61.10)415 (55.30)1.00 (RV)
T allele286 (38.90)335 (44.70)0.0230.79 (0.64 to 0.97)
HWE p value‡0.230.22
c.-2004 A→GAA138 (37.60)113 (30.10)0.099†1.00 (RV)
AG171 (46.60)196 (52.30)0.0410.71 (0.52 to 0.99)
GG58 (15.80)66 (17.60)0.1350.72 (0.47 to 1.11)
AG/GG229 (62.40)262 (69.90)0.0320.72 (0.53 to 0.97)
A allele447 (60.90)422 (56.30)1.00 (RV)
G allele287 (39.10)328 (43.70)0.0700.83 (0.67 to 1.02)
HWE p value‡0.680.23
c.-1896(ACA)1→(ACA)2(ACA)1(ACA)1126 (33.60)118 (30.30)0.538†1.00 (RV)
(ACA)1(ACA)2185 (49.30)207 (53.20)0.2760.84 (0.61 to 1.15)
(ACA)2(ACA)264 (17.10)64 (16.50)0.7640.94 (0.61 to 1.44)
(ACA)1(ACA)2/(ACA)2(ACA)2249 (66.40)271 (69.70)0.3330.86 (0.63 to 1.17)
(ACA)1allele437 (58.30)443 (56.90)1.00 (RV)
(ACA)2allele313 (41.70)335 (43.10)0.6000.95 (0.77 to 1.16)
HWE p value‡0.780.09
  • HWE, Hardy–Weinberg equilibrium; RV, reference value.

  • *Test of genotype and allele distribution in cases and controls by χ2 test (df = 1).

  • †Test of overall genotype distribution in cases and controls by χ2 test (df = 2).

  • ‡p Values for HWE were calculated by χ2 test, df = 1.

  • Significant p values are in bold type.