Outcome | Exposure | Timing of initiation of current regular farm animal contact | |||
Current farm animal contact initiated within last 12 months | Current farm animal contact initiated after first year but >12 months | Current farm animal contact initiated during first year | Overall interaction p value* | ||
SNPs with genotype strata | OR (95% CI) | OR (95% CI) | OR (95% CI) | ||
rs323917 | |||||
Asthma | CC (non-risk) | 0.73 (0.46 to 1.19) | 0.69 (0.38 to 1.24) | 0.75 (0.48 to 1.16) | 0.272 |
CG/GG | 1.16 (0.36 to 3.73) | 2.12 (0.70 to 6.46) | 0.58 (0.18 to 1.85) | ||
Rhinoconjunctivitis | CC | 0.77 (0.45 to 1.31) | 0.75 (0.33 to 1.44) | 0.51 (0.29 to 0.87) | 0.915 |
CG/GG | 1.10 (0.34 to 3.52) | 1.10 (0.29 to 4.13) | 0.62 (0.19 to 2.00) | ||
rs323922 | |||||
Asthma | CG/GG (non-risk) | 1.02 (0.62 to 1.68) | 1.00 (0.66 to 1.80) | 0.95 (0.61 to 1.51) | 0.060 |
CC | 0.34 (0.10 to 1.14) | 0.44 (0.13 to 1.51) | 0.36 (0.14 to 0.91) | ||
Rhinoconjunctivitis | CG/GG | 1.06 (0.63 to 1.79) | 0.97 (0.51 to 1.83) | 0.60 (0.34 to 1.04) | 0.038 |
CC | 0.12 (0.02 to 0.90) | 0.38 (0.09 to 1.66) | 0.39 (0.14 to 1.08) | ||
rs324377 | |||||
Asthma | AC/CC (non-risk) | 1.07 (0.65 to 1.76) | 0.95 (0.52 to 1.76) | 0.91 (0.57 to 1.46) | 0.095 |
AA | 0.32 (0.10 to 1.08) | 0.54 (0.18 to 1.59) | 0.43 (0.19 to 0.99) | ||
Rhinoconjunctivitis | AC/CC | 1.10 (0.64 to 1.88) | 1.04 (0.54 to 2.01) | 0.50 (0.27 to 0.92) | 0.021 |
AA | 0.12 (0.02 to 0.87) | 0.34 (0.08 to 1.50) | 0.50 (0.20 to 1.22) | ||
SNP546333 | |||||
Asthma | AA/AG (non-risk) | 0.18 (0.02 to 1.40) | 5e-8 (3e-8 to 8e-8) | 0.99 (0.41 to 2.38) | 0.005 |
GG | 0.93 (0.58 to 1.48) | 1.01 (0.39 to 1.72) | 0.73 (0.47 to 1.15) | ||
Rhinoconjunctivitis | AA/AG | 0.21 (0.03 to 1.58) | 0.35 (0.05 to 2.74) | 0.16 (0.02 to 1.20) | 0.160 |
GG | 0.92 (0.56 to 1.52) | 0.88 (0.48 to 1.63) | 0.60 (0.36 to 1.00) | ||
rs324384 | |||||
Asthma | CT/CC (non-risk) | 0.99 (0.59 to 1.66) | 0.93 (0.49 to 1.75) | 0.86 (0.53 to 1.39) | 0.471 |
TT | 0.50 (0.21 to 1.22) | 0.69 (0.30 to 1.61) | 0.60 (0.31 to 1.14) | ||
Rhinoconjunctivitis | CT/CC | 0.86 (0.48 to 1.54) | 1.06 (0.55 to 2.05) | 0.54 (0.29 to 0.98) | 0.495 |
TT | 0.71 (0.31 to 1.64) | 0.40 (0.12 to 1.35) | 0.54 (0.25 to 1.15) | ||
rs324396 | |||||
Asthma | CT/TT (non-risk) | 1.19 (0.65 to 2.16) | 0.98 (0.48 to 2.01) | 0.84 (0.48 to 1.47) | 0.327 |
CC | 0.53 (0.27 to 1.03) | 0.71 (0.35 to 1.45) | 0.70 (0.42 to 1.18) | ||
Rhinoconjunctivitis | CT/TT | 0.72 (0.35 to 1.49) | 1.18 (0.59 to 2.36) | 0.34 (0.16 to 0.80) | 0.128 |
CC | 0.79 (0.41 to 1.53) | 0.42 (0.15 to 1.21) | 0.66 (0.36 to 1.23) | ||
rs740347 | |||||
Asthma | GG (non-risk) | 1.07 (0.66 to 1.75) | 1.27 (0.74 to 2.19) | 0.75 (0.47 to 1.21) | NA† |
CC/CG | 0.27 (0.08 to 0.90) | NA* | 0.90 (0.47 to 1.72) | ||
Rhinoconjunctivitis | GG | 1.11 (0.66 to 1.87) | 0.93 (0.48 to 1.81) | 0.61 (0.34 to 1.07) | 0.063 |
CC/CG | 0.21 (0.05 to 0.88) | 0.53 (0.16 to 1.79) | 0.34 (0.13 to 0.93) |
PARSIFAL, Prevention of Allergy Risk factors for Sensitisation In children related to Farming and Anthroposophic Lifestyle.
Odds ratios (OR) and 95% confidence intervals (CI) from a logistic regression model, adjusting for gender, heredity and study group.
*Interaction as tested by the likelihood ratio (LR) test for the improvement of the model when including the interaction term.
†NA means that cases are missing for this combination, thus no OR or overall interaction p value can be calculated.