Table 5 The effect of initiation of current regular farm animal contact on asthma and rhinoconjunctivitis is modified by NPSR1 genotypes, among all PARSIFAL children
OutcomeExposureTiming of initiation of current regular farm animal contact
Current farm animal contact initiated within last 12 monthsCurrent farm animal contact initiated after first year but >12 monthsCurrent farm animal contact initiated during first yearOverall interaction p value*
SNPs with genotype strataOR (95% CI)OR (95% CI)OR (95% CI)
rs323917
AsthmaCC (non-risk)0.73 (0.46 to 1.19)0.69 (0.38 to 1.24)0.75 (0.48 to 1.16)0.272
CG/GG1.16 (0.36 to 3.73)2.12 (0.70 to 6.46)0.58 (0.18 to 1.85)
RhinoconjunctivitisCC0.77 (0.45 to 1.31)0.75 (0.33 to 1.44)0.51 (0.29 to 0.87)0.915
CG/GG1.10 (0.34 to 3.52)1.10 (0.29 to 4.13)0.62 (0.19 to 2.00)
rs323922
AsthmaCG/GG (non-risk)1.02 (0.62 to 1.68)1.00 (0.66 to 1.80)0.95 (0.61 to 1.51)0.060
CC0.34 (0.10 to 1.14)0.44 (0.13 to 1.51)0.36 (0.14 to 0.91)
RhinoconjunctivitisCG/GG1.06 (0.63 to 1.79)0.97 (0.51 to 1.83)0.60 (0.34 to 1.04)0.038
CC0.12 (0.02 to 0.90)0.38 (0.09 to 1.66)0.39 (0.14 to 1.08)
rs324377
AsthmaAC/CC (non-risk)1.07 (0.65 to 1.76)0.95 (0.52 to 1.76)0.91 (0.57 to 1.46)0.095
AA0.32 (0.10 to 1.08)0.54 (0.18 to 1.59)0.43 (0.19 to 0.99)
RhinoconjunctivitisAC/CC1.10 (0.64 to 1.88)1.04 (0.54 to 2.01)0.50 (0.27 to 0.92)0.021
AA0.12 (0.02 to 0.87)0.34 (0.08 to 1.50)0.50 (0.20 to 1.22)
SNP546333
AsthmaAA/AG (non-risk)0.18 (0.02 to 1.40)5e-8 (3e-8 to 8e-8)0.99 (0.41 to 2.38)0.005
GG0.93 (0.58 to 1.48)1.01 (0.39 to 1.72)0.73 (0.47 to 1.15)
RhinoconjunctivitisAA/AG0.21 (0.03 to 1.58)0.35 (0.05 to 2.74)0.16 (0.02 to 1.20)0.160
GG0.92 (0.56 to 1.52)0.88 (0.48 to 1.63)0.60 (0.36 to 1.00)
rs324384
AsthmaCT/CC (non-risk)0.99 (0.59 to 1.66)0.93 (0.49 to 1.75)0.86 (0.53 to 1.39)0.471
TT0.50 (0.21 to 1.22)0.69 (0.30 to 1.61)0.60 (0.31 to 1.14)
RhinoconjunctivitisCT/CC0.86 (0.48 to 1.54)1.06 (0.55 to 2.05)0.54 (0.29 to 0.98)0.495
TT0.71 (0.31 to 1.64)0.40 (0.12 to 1.35)0.54 (0.25 to 1.15)
rs324396
AsthmaCT/TT (non-risk)1.19 (0.65 to 2.16)0.98 (0.48 to 2.01)0.84 (0.48 to 1.47)0.327
CC0.53 (0.27 to 1.03)0.71 (0.35 to 1.45)0.70 (0.42 to 1.18)
RhinoconjunctivitisCT/TT0.72 (0.35 to 1.49)1.18 (0.59 to 2.36)0.34 (0.16 to 0.80)0.128
CC0.79 (0.41 to 1.53)0.42 (0.15 to 1.21)0.66 (0.36 to 1.23)
rs740347
AsthmaGG (non-risk)1.07 (0.66 to 1.75)1.27 (0.74 to 2.19)0.75 (0.47 to 1.21)NA†
CC/CG0.27 (0.08 to 0.90)NA*0.90 (0.47 to 1.72)
RhinoconjunctivitisGG1.11 (0.66 to 1.87)0.93 (0.48 to 1.81)0.61 (0.34 to 1.07)0.063
CC/CG0.21 (0.05 to 0.88)0.53 (0.16 to 1.79)0.34 (0.13 to 0.93)
  • PARSIFAL, Prevention of Allergy Risk factors for Sensitisation In children related to Farming and Anthroposophic Lifestyle.

  • Odds ratios (OR) and 95% confidence intervals (CI) from a logistic regression model, adjusting for gender, heredity and study group.

  • *Interaction as tested by the likelihood ratio (LR) test for the improvement of the model when including the interaction term.

  • †NA means that cases are missing for this combination, thus no OR or overall interaction p value can be calculated.