Table 4 The effect of initiation of current regular farm animal contact on allergic symptoms* is modified by NPSR1 genotypes, among all PARSIFAL children and in farmer and non-farmer subgroups
ExposureTiming of initiation of current regular farm animal contact
Current farm animal contact initiated within last 12 monthsCurrent farm animal contact initiated after first year but >12 months agoCurrent farm animal contact initiated during first yearOverall interaction p value†
SNPs with genotype strataOR (95% CI), all childrenAll childrenNon-farm children‡Farm children
rs3239170.40180.49290.4880
CC0.74 (0.50 to 1.12)0.77 (0.48 to 1.24)0.66 (0.45 to 0.96)
CG/GG1.23 (0.49 to 3.12)1.80 (0.69 to 4.71)0.73 (0.31 to 1.75)
rs3239220.00280.05990.0844
CG/GG1.08 (0.72 to 1.61)1.10 (0.69 to 1.76)0.84 (0.57 to 1.23)
CC0.19 (0.06 to 0.65)0.37 (0.13 to 1.10)0.39 (0.18 to 0.82)
rs3243770.00330.03250.1570
AC/CC1.12 (0.74 to 1.69)1.10 (0.67 to 1.79)0.79 (0.53 to 1.18)
AA0.19 (0.06 to 0.62)0.43 (0.16 to 1.14)0.46 (0.23 to 0.90)
SNP5463330.02880.10760.0305
AA/AG0.22 (0.05 to 0.97)0.17 (0.02 to 1.30)0.74 (0.33 to 1.66)
GG0.93 (0.63 to 1.37)1.03 (0.66 to 1.60)0.69 (0.48 to 1.00)
rs3243840.25990.70490.5939
CT/CC0.99 (0.64 to 1.51)1.08 (0.66 to 1.78)0.76 (0.51 to 1.15)
TT0.53 (0.26 to 1.08)0.59 (0.28 to 1.24)0.58 (0.34 to 1.01)
rs3243960.12450.41860.3298
CT/TT1.10 (0.66 to 1.82)1.20 (0.70 to 2.09)0.67 (0.41 to 1.09)
CC0.56 (0.33 to 0.96)0.62 (0.33 to 1.16)0.68 (0.44 to 1.06)
rs7403470.00060.02780.0351
GG1.11 (0.75 to 1.67)1.20 (0.76 to 1.91)0.72 (0.48 to 1.07)
CC/CG0.22 (0.08 to 0.63)0.26 (0.08 to 0.85)0.70 (0.39 to 1.26)
  • PARSIFAL, Prevention of Allergy Risk factors for Sensitisation In children related to Farming and Anthroposophic Lifestyle; SNP, single nucleotide polymorphism.

  • Odds ratios (OR) and 95% confidence intervals (CI) from a logistic regression model with all children, adjusting for gender, heredity and study group. The reference groups (no current regular farm contact, stratified by genotype, total n = 1622) are not shown.

  • *Doctor’s diagnosis of asthma and/or current symptoms of rhinoconjunctivitis.

  • †Interaction as tested by the likelihood ratio (LR) test for the improvement of the model when including the interaction term.

  • ‡Steiner school children combined with the two reference groups of the PARSIFAL study.