| Exposure | Timing of initiation of current regular farm animal contact | |||||
| Current farm animal contact initiated within last 12 months | Current farm animal contact initiated after first year but >12 months ago | Current farm animal contact initiated during first year | Overall interaction p value† | |||
| SNPs with genotype strata | OR (95% CI), all children | All children | Non-farm children‡ | Farm children | ||
| rs323917 | 0.4018 | 0.4929 | 0.4880 | |||
| CC | 0.74 (0.50 to 1.12) | 0.77 (0.48 to 1.24) | 0.66 (0.45 to 0.96) | |||
| CG/GG | 1.23 (0.49 to 3.12) | 1.80 (0.69 to 4.71) | 0.73 (0.31 to 1.75) | |||
| rs323922 | 0.0028 | 0.0599 | 0.0844 | |||
| CG/GG | 1.08 (0.72 to 1.61) | 1.10 (0.69 to 1.76) | 0.84 (0.57 to 1.23) | |||
| CC | 0.19 (0.06 to 0.65) | 0.37 (0.13 to 1.10) | 0.39 (0.18 to 0.82) | |||
| rs324377 | 0.0033 | 0.0325 | 0.1570 | |||
| AC/CC | 1.12 (0.74 to 1.69) | 1.10 (0.67 to 1.79) | 0.79 (0.53 to 1.18) | |||
| AA | 0.19 (0.06 to 0.62) | 0.43 (0.16 to 1.14) | 0.46 (0.23 to 0.90) | |||
| SNP546333 | 0.0288 | 0.1076 | 0.0305 | |||
| AA/AG | 0.22 (0.05 to 0.97) | 0.17 (0.02 to 1.30) | 0.74 (0.33 to 1.66) | |||
| GG | 0.93 (0.63 to 1.37) | 1.03 (0.66 to 1.60) | 0.69 (0.48 to 1.00) | |||
| rs324384 | 0.2599 | 0.7049 | 0.5939 | |||
| CT/CC | 0.99 (0.64 to 1.51) | 1.08 (0.66 to 1.78) | 0.76 (0.51 to 1.15) | |||
| TT | 0.53 (0.26 to 1.08) | 0.59 (0.28 to 1.24) | 0.58 (0.34 to 1.01) | |||
| rs324396 | 0.1245 | 0.4186 | 0.3298 | |||
| CT/TT | 1.10 (0.66 to 1.82) | 1.20 (0.70 to 2.09) | 0.67 (0.41 to 1.09) | |||
| CC | 0.56 (0.33 to 0.96) | 0.62 (0.33 to 1.16) | 0.68 (0.44 to 1.06) | |||
| rs740347 | 0.0006 | 0.0278 | 0.0351 | |||
| GG | 1.11 (0.75 to 1.67) | 1.20 (0.76 to 1.91) | 0.72 (0.48 to 1.07) | |||
| CC/CG | 0.22 (0.08 to 0.63) | 0.26 (0.08 to 0.85) | 0.70 (0.39 to 1.26) | |||
PARSIFAL, Prevention of Allergy Risk factors for Sensitisation In children related to Farming and Anthroposophic Lifestyle; SNP, single nucleotide polymorphism.
Odds ratios (OR) and 95% confidence intervals (CI) from a logistic regression model with all children, adjusting for gender, heredity and study group. The reference groups (no current regular farm contact, stratified by genotype, total n = 1622) are not shown.
*Doctor’s diagnosis of asthma and/or current symptoms of rhinoconjunctivitis.
†Interaction as tested by the likelihood ratio (LR) test for the improvement of the model when including the interaction term.
‡Steiner school children combined with the two reference groups of the PARSIFAL study.